The diagnostic role of DNA methylation in sporadic endometrial cancer: a systematic review and meta-analysis
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Yu Fan1,*, Yu Wang2,*, Shaozhi Fu1, Linglin Yang1, Sheng Lin1, Qingze Fan3 and Qinglian Wen1
1The Department of Oncology, The Affiliated Hospital of Southwest Medical University, Luzhou City, Sichuan Province, P.R.China
2The Department of Health Examination, The Affiliated Hospital of Southwest Medical University, Luzhou City, Sichuan Province, P.R.China
3The Department of Pharmacy, The Affiliated Hospital of Southwest Medical University, Luzhou City, Sichuan Province, P.R.China
*These authors contributed equally to this work
Qinglian Wen, email: email@example.com
Keywords: DNA methylation; endometrial cancer; biomarker; diagnosis; meta-analysis
Received: September 19, 2017 Accepted: December 04, 2017 Published: December 20, 2017
Background: Although increasing numbers of methylated genes have been identified as biomarkers for endometrial cancer, the results have been inconsistent. We therefore carried out a systematic review and meta-analysis to evaluate the diagnostic accuracy of methylated genes as markers for sporadic endometrial cancer.
Results: A total of 22 studies including 1930 participants (sporadic endometrial cancer patients and normal individuals) met our eligibility criteria. The pooled sensitivity and specificity were 0.93 (95% confidence interval: 0.91−0.94) and 0.48 (95% confidence interval: 0.46–0.50), respectively. The area under the summary receiver operating characteristic curve was 0.8834. The presence of DNA methylation was significantly associated with lymph node metastasis of endometrial cancer (pooled odds ratio: 0.28, 95% confidence interval: 0.15–0.52, p < 0.001).
Materials and Methods: We searched the relevant literature systematically using the PubMed and Web of Science databases up to April 2017. Diagnostic accuracy variables were pooled and analyzed using Meta-DiSc software. Sensitivity analysis and publication bias were evaluated using Review Manager.
Conclusions: This meta-analysis suggests that the detection of DNA methylation is associated with lymph node metastasis, with high sensitivity but relatively low specificity for the diagnosis of sporadic endometrial cancer.
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