Research Papers:

Association of SNPs in the TIMP-2 gene and large artery atherosclerotic stroke in southern Chinese Han population

Tie Guo, Haizhen Hao, Lv Zhou, Feng Zhou and Dan Yu _

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Oncotarget. 2018; 9:4698-4706. https://doi.org/10.18632/oncotarget.23473

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Tie Guo1, Haizhen Hao1, Lv Zhou1, Feng Zhou1 and Dan Yu1

1Haikou Hospital of Xiangya Medical College of Central South University, Haikou, Hainan 570208, China

Correspondence to:

Dan Yu, email: [email protected]

Keywords: TIMP-2; single-nucleotide polymorphisms; large artery atherosclerotic stroke; southern Chinese Han population

Received: November 14, 2017     Accepted: December 05, 2017     Published: December 18, 2017


Tissue inhibitor of matrix metalloproteinase 2 (TIMP-2) regulates the extracellular matrix degradation, which involved in vascular remodeling and dysfunction, destabilization of atherosclerotic plaque and many other pathological processes. The rupture of atherosclerotic plaque is the trigger of Large artery atherosclerotic (LAA) stroke. We speculate that the Single nucleotide polymorphisms (SNPs) in TIMP-2 may have an association with LAA stroke. To prove this hypothesis, we conducted this case-control study. 250 LAA stroke patients and 250 healthy controls were collected for the analysis of TIMP-2 polymorphisms. Among six SNPs, we detected no deviation from Hardy-Weinberg equilibrium in control group. There was a significant difference in rs4789936 T allele frequency between patient and control groups (OR = 0.68, 95% CI = 0.51–0.91, P = 0.009), which means lower risk of LAA stroke. We observed the rs4789936 had a decreased risk of LAA stroke according to the codominant (OR = 0.64, 95% CI = 0.44–0.92, P = 0.026), dominant (OR = 0.62, 95% CI = 0.43-0.88, P = 0.008), overdominant (OR = 0.68, 95% CI = 0.48–0.98, P = 0.039), log-additive (OR = 0.68, 95% CI = 0.51–0.91, P = 0.009) models analyses. However, these findings could only validate under dominant model (OR = 0.65, 95% CI = 0.42–1.00, P = 0.049) after adjustment of gender and age. The results indicate a potential association between TIMP-2 variants and LAA stroke risk in southern Chinese Han population.

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