Pulmonary sarcomatoid carcinoma: University of Cincinnati experience

Nagla Abdel Karim; James Schuster; Ihab Eldessouki; Ola Gaber; Tariq Namad; Jiang Wang; Changchun Xie; John C. Morris

doi:10.18632/oncotarget.23468

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Research Papers:

Pulmonary sarcomatoid carcinoma: University of Cincinnati experience

Nagla Abdel Karim, James Schuster, Ihab Eldessouki, Ola Gaber _, Tariq Namad, Jiang Wang, Changchun Xie and John C. Morris

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Oncotarget. 2018; 9:4102-4108. https://doi.org/10.18632/oncotarget.23468

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Abstract

Nagla Abdel Karim1, James Schuster2, Ihab Eldessouki1, Ola Gaber1, Tariq Namad3, Jiang Wang4, Changchun Xie5 and John C. Morris1

1Vontz Center for Molecular Studies, University of Cincinnati, Cincinnati, OH 45219, USA

2University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA

3Military Hospital of Mohammed V, Department of Medical Oncology, Quartier Irfane, Rabat 10080, Morocco

4UC Health University Hospital, Department of Pathology and Laboratory Medicine, Cincinnati, OH 45219, USA

5Division of Biostatistics and Bioinformatics, Department of Environmental Health, Cincinnati, OH 45267, USA

Correspondence to:

Ola Gaber, email: [email protected]

Keywords: chemotherapy; lung cancer; non-small cell lung cancer; sarcomatoid

Received: October 10, 2017 Accepted: November 19, 2017 Published: December 18, 2017

ABSTRACT

Objectives: To review the outcomes of treatment in patients with pulmonary sarcomatoid carcinoma (PSC) treated at the University of Cincinnati Medical Center (UCMC).

Results: There was no significant difference in survival of patients treated with chemotherapy alone (median, 256 days) compared to patients not undergoing treatment (median, 205.5 days). Patients who underwent surgery and adjuvant chemotherapy showed a trend in improvement of survival (median, 457.6 days). Patients requiring only surgery had the longest OS of 713.5 days.

Conclusions: Systemic chemotherapy alone did not improve survival in patients with PSC. Surgery provides the greatest overall survival benefit and adjuvant chemotherapy may also improve survival.

Methods: From 2000 to 2014, twenty-five patients with pathologically confirmed PSC were treated at UCMC. The outcomes were retrospectively analyzed by treatment with overall survival (OS) as the endpoint.

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Research Papers:

Pulmonary sarcomatoid carcinoma: University of Cincinnati experience

Abstract