Research Papers:

Morphologic predictors of pathological complete response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer

Chongda Zhang, Feng Ye, Yuan Liu, Han Ouyang, Xinming Zhao and Hongmei Zhang _

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Oncotarget. 2018; 9:4862-4874. https://doi.org/10.18632/oncotarget.23419

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Chongda Zhang1, Feng Ye1, Yuan Liu1, Han Ouyang1, Xinming Zhao1 and Hongmei Zhang1

1Department of Diagnostic Radiology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 10021, China

Correspondence to:

Hongmei Zhang, email: [email protected]

Keywords: rectal cancer; magnetic resonance imaging; pathologically complete response; neoadjuvant chemoradiotherapy

Received: May 23, 2017    Accepted: October 02, 2017    Published: December 19, 2017


Purpose: To evaluate the value of morphological parameters that can be obtained conveniently by MRI for predicting pathologically complete response (pCR) in patients with rectal cancer.

Materials and Methods: A cohort of 101 patients was examined using MRI before and after Neoadjuvant chemoradiotherapy (nCRT). Morphological parameters including maximum tumor area (MTA), maximum tumor length (MTL) and maximum tumor thickness (MTT), as well as cylindrical approximated tumor volume (CATV), distance to anal verge (DTA), and the reduction rates were evaluated by two experienced readers independently.

Results: Post-nCRT MTA and MTL, reduction rates and pre-nCRT DTA were proved to be significantly different between pCR and non-pCR with the AUCs of 0.672-0.853. The sensitivity and specificity for assessing pCR were 61.1-89.9% and 59.0-80.7% respectively. No significant correlation between pre-nCRT size measurements and pCR was obtained.

Conclusion: The convenient morphological measurements may be useful for predicting pCR with moderate sensitivity and specificity. Combining these predictors with the aim of building diagnostic model should be explored.

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