Diagnostic value of circulating microRNAs for liver cirrhosis: a meta-analysis

Liwei Guo, Weiyan Li, Liyang Hu, Huanhuan Zhou, Lei Zheng, Lifei Yu and Weifeng Liang _

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Oncotarget. 2018; 9:5397-5405. https://doi.org/10.18632/oncotarget.23332

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Liwei Guo1,2,*, Weiyan Li3,*, Liyang Hu1,2, Huanhuan Zhou4, Lei Zheng4, Lifei Yu5 and Weifeng Liang1,2

1State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China

2Shengzhou People’s Hospital, Shengzhou Branch of the First Affiliated Hospital of Zhejiang University, Shengzhou, China

3Shanghai Ninth People’s Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China

4Institute of Cancer Research, Zhejiang Cancer Hospital, Hangzhou, China

5Department of Infectious Diseases, Hangzhou First People's Hospital, Nanjing Medical University, Hangzhou, China

*These authors contributed equally to this work

Correspondence to:

Weifeng Liang, email: [email protected]

Lifei Yu, email: [email protected]

Keywords: liver cirrhosis; circulating; microRNA; diagnosis; meta-analysis

Received: July 27, 2017     Accepted: December 13, 2017     Published: December 16, 2017


Circulating microRNAs are potential biomarkers for various diseases including liver cirrhosis. We designed a meta-analysis to evaluate the diagnostic value of circulating microRNAs for liver cirrhosis patients. Eligible studies were identified by searching PubMed, Embase, and the Cochrane Library up to July 1, 2017. The diagnostic sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR), and area under the receiver operating characteristic (AUROC) curve were analyzed using a random or fixed effects models based on the between-study heterogeneities. Thirteen studies from 7 articles with 627 patients and 418 healthy controls were included in this meta-analysis. All studies had high quality assessment scores. The pooled sensitivity, specificity, PLR, NLR, DOR and AUROC were 0.83 (95% CI: 0.80–0.86), 0.89 (95% CI: 0.86–0.92), 6.41 (95% CI: 3.93–10.44), 0.22 (95% CI: 0.14–0.33), 35.18 (95% CI: 15.90–77.81) and 0.93 (95% CI: 0.91–0.95), respectively. In conclusion, circulating microRNAs may serve as potential noninvasive biomarkers of liver cirrhosis.

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