No associations between fruit and vegetable consumption and pancreatic cancer risk: a meta-analysis of prospective studies

Zhanwei Zhao, Pengfei Yu, Xiangying Feng, Zifang Yin, Shiqi Wang, Zhaoyan Qiu and Qingchuan Zhao _

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Oncotarget. 2018; 9:32250-32261. https://doi.org/10.18632/oncotarget.23128

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Zhanwei Zhao1,2, Pengfei Yu2, Xiangying Feng2, Zifang Yin3, Shiqi Wang2, Zhaoyan Qiu4 and Qingchuan Zhao2

1Department of Surgery, Navy General Hospital of PLA, Beijing, China

2Xijing Hospital of Digestive Diseases, The Fourth Military Medical University, Xi'an, China

3Shaanxi Maternal and Child Health Hospital, Shaanxi Province, Xi'an, China

4The General Hospital of The People’s Liberation Army, Department of General Surgery, Beijing, China

Correspondence to:

Qingchuan Zhao, email: [email protected]

Keywords: meta-analysis; fruit; vegetable; pancreatic cancer; risk

Received: April 21, 2017     Accepted: November 14, 2017     Epub: December 08, 2017     Published: August 14, 2018


The associations between fruit and vegetable consumption and pancreatic cancer risk are inconclusive. We conducted a meta-analysis of prospective studies to investigate the associations. The search was conducted systemically using the PubMed and EMBASE databases up to March 2017. Relative risks and 95% confidence intervals for the highest versus lowest consumption and dose-response analyses were assessed. Subtype and subgroup analyses were performed. Twelve studies were eligible. The summary relative risks of the highest versus lowest consumption were 0.95 (0.80–1.12) for total fruits and vegetables without heterogeneity (I2 = 0%, P = 0.44), 0.96 (0.82–1.12) for fruits without low heterogeneity (I2 = 37%, P = 0.12) and 0.94 (0.84–1.06) for vegetables with low heterogeneity (I2 = 9%, P = 0.36). Dose-response analyses also showed no significantly inverse associations for each 100 g/day increase; the summary relative risks were 1.00 (0.98–1.02) for total fruits and vegetables, 1.01 (0.97–1.05) for fruits and 1.00 (0.97–1.03) for vegetables. The results of subtype analyses were consistent with the fruit and vegetable analyses; the relative risks were 0.97 (0.80–1.17) for citrus fruit without low heterogeneity (I2 = 39%, P = 0.15) and 0.89 (0.76–1.05) for cruciferous vegetables without low heterogeneity (I2 = 14%, P = 0.32). In conclusion, this meta-analysis does not support significant associations between fruit and vegetable consumption and pancreatic cancer risk.

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