Association of RTEL1 gene polymorphisms with stroke risk in a Chinese Han population
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Yi Cai1, Chaosheng Zeng1, Qingjie Su1, Jingxia Zhou1, Pengxiang Li1, Mingming Dai1, Desheng Wang1 and Faqing Long1
1Department of Neurosurgery, The Second Affiliated Hospital of Hainan Medical College, Hainan 570311, China
Faqing Long, email: [email protected]
Keywords: single nucleotide polymorphisms (SNPs); RTEL1; telomere; stroke; case-control study
Received: September 27, 2017 Accepted: November 15, 2017 Published: December 05, 2017
We investigated the associations between single nucleotide polymorphisms (SNPs) in the regulator of telomere elongation helicase 1 (RTEL1) gene and stroke in the Chinese population. A total of 400 stroke patients and 395 healthy participants were included in this study. Five SNPs in RTEL1 were genotyped and the association with stroke risk was analyzed. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated using unconditional logistic regression analysis. Multivariate logistic regression analysis was used to identify SNPs that correlated with stroke. Rs2297441 was associated with an increased risk of stroke in an allele model (odds ratio [OR] = 1.24, 95% confidence interval [95% CI] = 1.01–1.52, p = 0.043). Rs6089953 was associated with an increased risk of stroke under the genotype model ([OR] = 1.862, [CI] = 1.123–3.085, p = 0.016). Rs2297441 was associated with an increased risk of stroke in an additive model (OR = 1.234, 95% CI = 1.005, p = 0.045, Rs6089953,Rs6010620 and Rs6010621 were associated with an increased risk of stroke in the recessive model (Rs6089953:OR = 1.825, 95% CI = 1.121–2.969, p =0.01546; Rs6010620: OR = 1.64, 95% CI = 1.008–2.669, p =0.04656;Rs6010621:OR = 1.661, 95% CI = 1.014–2.722, p =0.04389). Our findings reveal a possible association between SNPs in the RTEL1 gene and stroke risk in Chinese population.
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