Meta-analysis of the correlation between Helicobacter pylori infection and autoimmune thyroid diseases
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Yi Hou1,2,*, Wen Sun1,*, Chengfei Zhang1,2, Tieshan Wang3, Xuan Guo1,2, Lili Wu3, Lingling Qin4 and Tonghua Liu1
1Key Laboratory of Health Cultivation of the Ministry of Education, Beijing University of Chinese Medicine, Beijing, 100029, People's Republic of China
2Dongfang Hospital of Beijing University of Chinese Medicine, Beijing, 100078, People's Republic of China
3Beijing Institute of Chinese Medicine, Beijing University of Chinese Medicine, Beijing, 100029, People's Republic of China
4Department of Science and Technology, Beijing University of Chinese Medicine, Beijing, 100029, People's Republic of China
*These authors contributed equally to this work
Tonghua Liu, email: firstname.lastname@example.org
Keywords: helicobacter pylori infection; AITD; meta-analysis
Received: May 26, 2017 Accepted: November 14, 2017 Published: December 04, 2017
Objective: This study presents a systematic meta-analysis of the correlation between Helicobacter pylori (H. pylori) infection and autoimmune thyroid diseases (AITD).
Materials and Methods: Fifteen articles including 3,046 cases were selected (1,716 observational and 1,330 control cases). These data were analyzed using Stata12.0 meta-analysis software.
Results: H. pylori infection was positively correlated with the occurrence of AITD (OR = 2.25, 95% CI: 1.72–2.93). Infection with H. pylori strains positive for the cytotoxin-associated gene A (CagA) were positively correlated with AITD (OR = 1.99, 95% CI: 1.07–3.70). There was no significant difference between infections detected using enzyme-linked immunosorbent assay (ELISA) and other methods (χ2 = 2.151, p = 0.143). Patients with Grave’s disease (GD) and Hashimoto’s thyroiditis (HT) were more susceptible to H. pylori infection (GD: OR = 2.78, 95% CI: 1.68–4.61; HT: OR = 2.16, 95% CI: 1.44–3.23), while the rate of H. pylori infection did not differ between GD and HT (χ2 = 3.113, p = 0.078).
Conclusions: H. pylori infection correlated with GD and HT, and the eradication of H. pylori infection could reduce thyroid autoantibodies.
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