Oncotarget

Meta-Analysis:

Meta-analysis of the correlation between Helicobacter pylori infection and autoimmune thyroid diseases

Yi Hou, Wen Sun, Chengfei Zhang, Tieshan Wang, Xuan Guo, Lili Wu, Lingling Qin and Tonghua Liu _

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Oncotarget. 2017; 8:115691-115700. https://doi.org/10.18632/oncotarget.22929

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Abstract

Yi Hou1,2,*, Wen Sun1,*, Chengfei Zhang1,2, Tieshan Wang3, Xuan Guo1,2, Lili Wu3, Lingling Qin4 and Tonghua Liu1

1Key Laboratory of Health Cultivation of the Ministry of Education, Beijing University of Chinese Medicine, Beijing, 100029, People's Republic of China

2Dongfang Hospital of Beijing University of Chinese Medicine, Beijing, 100078, People's Republic of China

3Beijing Institute of Chinese Medicine, Beijing University of Chinese Medicine, Beijing, 100029, People's Republic of China

4Department of Science and Technology, Beijing University of Chinese Medicine, Beijing, 100029, People's Republic of China

*These authors contributed equally to this work

Correspondence to:

Tonghua Liu, email: thliu@vip.163.com

Keywords: helicobacter pylori infection; AITD; meta-analysis

Received: May 26, 2017     Accepted: November 14, 2017     Published: December 04, 2017

ABSTRACT

Objective: This study presents a systematic meta-analysis of the correlation between Helicobacter pylori (H. pylori) infection and autoimmune thyroid diseases (AITD).

Materials and Methods: Fifteen articles including 3,046 cases were selected (1,716 observational and 1,330 control cases). These data were analyzed using Stata12.0 meta-analysis software.

Results: H. pylori infection was positively correlated with the occurrence of AITD (OR = 2.25, 95% CI: 1.72–2.93). Infection with H. pylori strains positive for the cytotoxin-associated gene A (CagA) were positively correlated with AITD (OR = 1.99, 95% CI: 1.07–3.70). There was no significant difference between infections detected using enzyme-linked immunosorbent assay (ELISA) and other methods (χ2 = 2.151, p = 0.143). Patients with Grave’s disease (GD) and Hashimoto’s thyroiditis (HT) were more susceptible to H. pylori infection (GD: OR = 2.78, 95% CI: 1.68–4.61; HT: OR = 2.16, 95% CI: 1.44–3.23), while the rate of H. pylori infection did not differ between GD and HT (χ2 = 3.113, p = 0.078).

Conclusions: H. pylori infection correlated with GD and HT, and the eradication of H. pylori infection could reduce thyroid autoantibodies.


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