Oncotarget

Research Papers:

Up-regulation of lncRNA SNHG1 indicates poor prognosis and promotes cell proliferation and metastasis of colorectal cancer by activation of the Wnt/β-catenin signaling pathway

Yuping Zhu, Bo Li, Zhuo Liu, Lai Jiang, Gang Wang, Min Lv and Dechuan Li _

PDF  |  HTML  |  How to cite  |  Order a Reprint

Oncotarget. 2017; 8:111715-111727. https://doi.org/10.18632/oncotarget.22903

Metrics: PDF 559 views  |   HTML 923 views  |   ?  


Abstract

Yuping Zhu1, Bo Li1, Zhuo Liu1, Lai Jiang1, Gang Wang1, Min Lv2 and Dechuan Li1

1Department of Colorectal Surgery, Zhejiang Cancer Hospital, Hangzhou 310022, Zhejiang Province, China

2Department of Ultrasonic, Zhejiang Cancer Hospital, Hangzhou 310022, Zhejiang Province, China

Correspondence to:

Dechuan Li, email: lidechuanpro@sina.com

Keywords: colorectal cancer; SNHG1; Wnt/β-catenin; proliferation; metastasis

Received: June 19, 2017    Accepted: November 16, 2017    Published: December 04, 2017

ABSTRACT

Recently, the lncRNA small nucleolar RNA host gene (SNHG1) has been exhibited to be upregulated, which plays a crucial role in the development and prognosis of several cancers. However, the role of the biology and clinical significance of SNHG1 in the tumorigenesis of colorectal cancer (CRC) has rarely been reported. In this work, we firstly found that SNHG1 expression levels were upregulated aberrantly in colorectal cancer tissues and colorectal cancer cell lines. By Kaplan-Meier survival analysis, patients with high SNHG1 expression level had poorer overall survival (OS) and progression-free survival (PFS) than those with low SNHG1 expression. In multivariate analysis, increased SNHG1 expression was proved to be an independent unfavorable prognostic indicator for CRC. In vitro experiments revealed that SNHG1 silencing inhibited the growth and metastasis and induced apoptosis of CRC cell lines. Finally, we found that SNHG1 may induce the activation of the WNT/β-catenin pathway through regulating β-catenin expression and transcription factor-4 (TCF-4), cyclin D1 and MMP-9. Altogether, our findings demonstrated that lncRNA SNHG1, was high expressed in colorectal cancer tissues and may serve as a tumor oncogene through regulating WNT/β-catenin signal pathway, which provided a candidate diagnostic biomarker and a promising therapeutic target for patients with CRC.


Creative Commons License All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 3.0 License.
PII: 22903