Research Papers:

Intrahepatic cholangiocarcinoma patients without indications of lymph node metastasis not benefit from lymph node dissection

Jie Hu, Fei-Yu Chen, Kai-Qian Zhou, Cheng Zhou, Ya Cao, Hui-Chuan Sun, Jia Fan, Jian Zhou and Zheng Wang _

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Oncotarget. 2017; 8:113817-113827. https://doi.org/10.18632/oncotarget.22852

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Jie Hu1,*, Fei-Yu Chen1,*, Kai-Qian Zhou1,*, Cheng Zhou1, Ya Cao2, Hui-Chuan Sun1, Jia Fan1,3,4,5, Jian Zhou1,3,4,5 and Zheng Wang1

1Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, Key Laboratory of Carcinogenesis and Cancer Invasion, Fudan University, Ministry of Education, Shanghai, China

2Cancer Research Institute, Xiangya School of Medicine, Central South University, Hunan, China

3State Key Laboratory of Genetic Engineering, Fudan University, Shanghai, China

4Shanghai Key Laboratory of Organ Transplantation, Zhongshan Hospital, Fudan University, Shanghai, China

5Institute of Biomedical Sciences, Fudan University, Shanghai, China

*These authors have contributed equally to this work

Correspondence to:

Zheng Wang, email: [email protected]

Jian Zhou, email: [email protected]

Keywords: intrahepatic cholangiocarcinoma; lymph node metastasis; lymph node dissection; prognosis

Received: September 15, 2017    Accepted: November 13, 2017    Published: December 01, 2017


Background: To investigate the necessity of routine lymph node dissection (LND) in intrahepatic cholangiocarcinoma (ICC) patients without indications of lymph node metastasis (LNM) preoperatively. Methods: 422 consecutive ICC patients who undergone curative resection from January 2009 to December 2014 were enrolled and categorized as two groups (hepatectomy only or hepatectomy plus LND). Clinicopathologic data was compared between the groups by χ2 or Fisher’s exact test. Overall survival (OS) and recurrence-free survival (RFS) were calculated by the Kaplan–Meier method and differences were analyzed using the log-rank test. Cox regression model was adopted for multivariable analysis. Results: The median OS time of all 422 patients was 41.4 months. One-, 3-, and 5-year OS was 67%, 47%, and 35%, respectively. A total of 73 patients had undergone curative resection combined with LND, of whom 20.5% (15/73) were confirmed lymph node positive pathologically. The clinicopathologic characteristics between LND and control groups showed no significant differences. Of the 422 patients, 271 patients had recurrence. The recurrence rates were 65.8% for the LND group and 63.9% for the non-LND group. Survival analysis revealed that, neither the OS (LND vs. non-LND: 32.2 months vs. 46.2 months; p = 0.16) nor the RFS (LND vs. non-LND: 23.1 months vs. 17.0 months; p = 0.09) had significant difference. Multivariate analysis revealed that tumor size, tumor number, carbohydrate antigen19-9, carcinoembryonic antigen, and gamma-glutamyl transpeptidase were independent predictive factors for OS and RFS. Conclusion: Routine LND may not improve survival in resectable ICC patients with negative LNM diagnosis before operation.

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