Research Papers:
Impaired epidermal Langerhans cell maturation in TGFβ-inducible early gene 1 (TIEG1) knockout mice
PDF | HTML | How to cite
Metrics: PDF 1750 views | HTML 2048 views | ?
Abstract
Xilin Zhang1,3, Yi Yao1,2, Wei-Zen Wei4, Zeng-Quan Yang4, Jun Gu3 and Li Zhou1,2,5
1Center for Cutaneous Biology and Immunology Research, Department of Dermatology, Henry Ford Health System, Detroit, MI, USA
2Immunology Research Program, Henry Ford Cancer Institute, Henry Ford Health System, Detroit, MI, USA
3Department of Dermatology, Second Military Medical University Changhai Hospital, Shanghai, China
4Karmanos Cancer Institute, Wayne State University, Detroit, MI, USA
5Department of Internal Medicine, Henry Ford Health System, Detroit, MI, USA
Correspondence to:
Li Zhou, email: [email protected]
Jun Gu, email: [email protected]
Keywords: Langerhans cell; TIEG1; maturation; TGF-β1 signaling
Received: May 30, 2017 Accepted: November 11, 2017 Published: December 01, 2017
ABSTRACT
TGF-β-inducible early gene 1 (TIEG1), also known as Krüppel-like factor 10 (Klf10), represents a major downstream transcription factor of transforming growth factor-β1 (TGF-β1) signaling. Epidermal Langerhans cells (LCs), a unique subpopulation of dendritic cells (DC), essentially mediates immune surveillance and tolerance. TGF-β1 plays a pivotal role in LC maintenance and function after birth, although the underpinning mechanisms remain elusive. Here, we hypothesized that TIEG1 might be involved in TGF-β1-mediated LC homeostasis and function. Utilizing TIEG1 null mice, we discovered that TIEG1 deficiency did not alter LC homeostasis at the steady state and LC repopulation at inflamed-state, as well as their antigen-uptake capacity, but significantly impaired their maturation ability, which was opposite to the fact that loss of TGF-β1 induced spontaneous LC maturation. Moreover, the ablation of TIEG1 enhanced skin contact hypersensitivity response. Our results suggested that TIEG1 is not a key molecule involved in TGF-β1-mediated homeostasis, while TIEG1-related signaling pathways regulate LC maturation and their function.
All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 4.0 License.
PII: 22843