The effects of tumor necrosis factor-α (TNF-α) rs1800629 and rs361525 polymorphisms on sepsis risk
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Yixin Zhang1,2,*, Xiaoteng Cui3,*, Li Ning1 and Dianjun Wei1
1Department of Clinical Laboratory, The Second Hospital of Tianjin Medical University, Tianjin 300211, PR China
2School of Medical Laboratory, Tianjin Medical University, Tianjin 300070, PR China
3Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, PR China
*These authors have contributed equally to this work
Dianjun Wei, email: firstname.lastname@example.org
Keywords: tumor necrosis factor-α; single nucleotide polymorphisms; sepsis; rs1800629; rs361525
Received: September 16, 2017 Accepted: November 13, 2017 Published: November 30, 2017
This meta-analysis of 23 eligible articles comprehensively and quantitatively evaluated the effects of tumor necrosis factor-α (TNF-α) rs1800629 and rs361525 polymorphisms on sepsis risk. We found that TNF-α rs1800629 was associated with increased sepsis risk in the overall population in four genetic models, including A vs. G (P<0.001, odds ratio (OR)=1.32), GA vs. GG (P<0.001, OR=1.46), GA+AA vs. GG (P<0.001, OR=1.46), and carrier A vs. carrier G (P<0.001, OR=1.32). Subgroup analyses showed a similar result for Asian patients (all P<0.05, OR>1). TNF-α rs361525 was also associated with increased sepsis risk in Asian patients in the four genetic models (all P<0.05, OR>1). Begg’s and Egger’s tests excluded large publication bias, and sensitivity analysis indicated stable results. Our results suggest that the G/A genotype of TNF-α rs1800629 and rs361525 increases sepsis risk in an Asian population.
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