IL-36 cytokines in autoimmunity and inflammatory disease

Liping Ding, Xiaohui Wang, Xiaoping Hong, Liwei Lu and Dongzhou Liu _

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Oncotarget. 2018; 9:2895-2901. https://doi.org/10.18632/oncotarget.22814

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Liping Ding1, Xiaohui Wang2, Xiaoping Hong1, Liwei Lu2 and Dongzhou Liu1

1Department of Rheumatology and Immunology, Shenzhen People’s Hospital, The Second Clinical Medical College of Jinan University, Shenzhen, China

2Department of Pathology and Shenzhen Institute of Research and Innovation, The University of Hong Kong, Hong Kong, China

Correspondence to:

Dongzhou Liu, email: [email protected]

Liwei Lu, email: [email protected]

Keywords: interleukin-36; inflammatory disease; psoriasis; arthritis

Received: September 29, 2017     Accepted: October 29, 2017     Published: December 01, 2017


The inteleukin-36 (IL-36) cytokines include IL-36α, IL-36β, IL-36γ and IL-36Ra, which belong to the IL-1 family and exert pro-inflammatory effects on various target cells such as keratinocytes, synoviocytes, dendritic cells and T cells. Emerging evidence has suggested a role of IL-36 in the pathogenesis of many inflammatory diseases. Here, we provide a brief review on the activation of IL-36 family cytokines and their involvement in autoimmunity and inflammatory diseases, which will provide further insights in understanding the functions of IL-36 family cytokines in the pathophysiology of autoimmunity and inflammatory diseases.

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