Cancer risk susceptibility loci in a Swedish population
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Wen Liu1, Xiang Jiao1, Jessada Thutkawkorapin1, Hovsep Mahdessian1 and Annika Lindblom1
1Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
Annika Lindblom, email: [email protected]
Keywords: genome-wide association study; haplotype association analysis; cancer syndrome; cancer risk; cancer predisposition
Received: September 04, 2017 Accepted: October 27, 2017 Published: November 25, 2017
A germline mutation in cancer predisposing genes is known to increase the risk of more than one tumor type. In order to find loci associated with many types of cancer, a genome-wide association study (GWAS) was conducted, and 3,555 Swedish cancer cases and 15,581 controls were analyzed for 226,883 SNPs. The study used haplotype analysis instead of single SNP analysis in order to find putative founder effects. Haplotype association studies identified seven risk loci associated with cancer risk, on chromosomes 1, 7, 11, 14, 16, 17 and 21. Four of the haplotypes, on chromosomes 7, 14, 16 and 17, were confirmed in Swedish familial cancer cases. It was possible to perform exome sequencing in one patient for each of those four loci. No clear disease-causing exonic mutation was found in any of the four loci. Some of the candidate loci hold several cancer genes, suggesting that the risk associated with one locus could involve more than one gene associated with cancer risk. In summary, this study identified seven novel candidate loci associated with cancer risk. It was also suggested that cancer risk at one locus could depend on multiple contributing risk mutations/genes.
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