Research Papers:

Predictive value of different proportion of lesion HLA-G expression in colorectal cancer

Rui-Li Zhang, Xia Zhang, Shan-Shan Dong, Bing Hu, Qiu-Yue Han, Jian-Gang Zhang, Wen-Jun Zhou, Aifen Lin _ and Wei-Hua Yan

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Oncotarget. 2017; 8:107441-107451. https://doi.org/10.18632/oncotarget.22487

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Rui-Li Zhang1, Xia Zhang2, Shan-Shan Dong2, Bing Hu3, Qiu-Yue Han2, Jian-Gang Zhang2, Wen-Jun Zhou2, Aifen Lin2 and Wei-Hua Yan3,4

1Department of Gastrointestinal Surgery, Taizhou Hospital of Zhejiang Province, Wenzhou Medical University, Linhai, Zhejiang, P.R. China

2Human Tissue Bank, Wenzhou Medical University affiliated Taizhou Hospital of Zhejiang Province, Linhai, Zhejiang, P.R. China

3Medical Research Center, Wenzhou Medical University affiliated Taizhou Hospital of Zhejiang Province, Linhai, Zhejiang, P.R. China

4Department of Laboratory Medicine, Xianju People’s Hospital, Xianju, Zhejiang, P.R. China

Correspondence to:

Aifen Lin, email: [email protected]

Wei-Hua Yan, email: [email protected]

Keywords: HLA-G; colorectal cancer; prognosis

Received: June 12, 2017     Accepted: October 28, 2017     Published: November 18, 2017


Differential expression of HLA-G has been observed among cancer types and tumors from individuals with the same type of cancer; however, its clinical significance is rather limited. In this study, expression and predictive relevance of HLA-G expression in 457 primary colorectal cancer (CRC, ncolon = 232, nrectal = 225) patients was investigated. Data showed 70.7% (323/457) of the CRC were HLA-G expression when the above 5% (HLA-GLow) was considered as positive, which wasn’t associated with patient survival (p = 0.109). However, HLA-G expression above 55% (HLA-GHigh) was associated with a worse prognosis of CRC patients (p = 0.042). Furthermore, a shorter survival was found for the female (p = 0.042) and elder (p = 0.037) patients whose HLA-G expression was above HLA-GLow level. HLA-G expression above HLA-GHigh level showed a worse prognosis for female (p = 0.013), elder (p = 0.023), colon cancer (p = 0.016), advanced tumor burden (T3+4, p = 0.018), regional lymph node status (N1+2, p = 0.044), and advanced clinical stage patients (AJCC III+IV, p = 0.037). In conclusion, our results demonstrated for the first time that combination of differential lesion HLA-G expression notably improved the value of traditional survival prediction for CRC patients.

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