Predictive value of different proportion of lesion HLA-G expression in colorectal cancer
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Rui-Li Zhang1, Xia Zhang2, Shan-Shan Dong2, Bing Hu3, Qiu-Yue Han2, Jian-Gang Zhang2, Wen-Jun Zhou2, Aifen Lin2 and Wei-Hua Yan3,4
1Department of Gastrointestinal Surgery, Taizhou Hospital of Zhejiang Province, Wenzhou Medical University, Linhai, Zhejiang, P.R. China
2Human Tissue Bank, Wenzhou Medical University affiliated Taizhou Hospital of Zhejiang Province, Linhai, Zhejiang, P.R. China
3Medical Research Center, Wenzhou Medical University affiliated Taizhou Hospital of Zhejiang Province, Linhai, Zhejiang, P.R. China
4Department of Laboratory Medicine, Xianju People’s Hospital, Xianju, Zhejiang, P.R. China
Aifen Lin, email: firstname.lastname@example.org
Wei-Hua Yan, email: email@example.com
Keywords: HLA-G; colorectal cancer; prognosis
Received: June 12, 2017 Accepted: October 28, 2017 Published: November 18, 2017
Differential expression of HLA-G has been observed among cancer types and tumors from individuals with the same type of cancer; however, its clinical significance is rather limited. In this study, expression and predictive relevance of HLA-G expression in 457 primary colorectal cancer (CRC, ncolon = 232, nrectal = 225) patients was investigated. Data showed 70.7% (323/457) of the CRC were HLA-G expression when the above 5% (HLA-GLow) was considered as positive, which wasn’t associated with patient survival (p = 0.109). However, HLA-G expression above 55% (HLA-GHigh) was associated with a worse prognosis of CRC patients (p = 0.042). Furthermore, a shorter survival was found for the female (p = 0.042) and elder (p = 0.037) patients whose HLA-G expression was above HLA-GLow level. HLA-G expression above HLA-GHigh level showed a worse prognosis for female (p = 0.013), elder (p = 0.023), colon cancer (p = 0.016), advanced tumor burden (T3+4, p = 0.018), regional lymph node status (N1+2, p = 0.044), and advanced clinical stage patients (AJCC III+IV, p = 0.037). In conclusion, our results demonstrated for the first time that combination of differential lesion HLA-G expression notably improved the value of traditional survival prediction for CRC patients.
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