Oncotarget

Research Papers:

Long noncoding RNA lncHERG promotes cell proliferation, migration and invasion in glioblastoma

Jian Shi _, Yong-Jie Wang, Chong-Ran Sun, Bin Qin, Yang Zhang and Gao Chen

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Oncotarget. 2017; 8:108031-108041. https://doi.org/10.18632/oncotarget.22446

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Abstract

Jian Shi1, Yong-Jie Wang1, Chong-Ran Sun1, Bin Qin1, Yang Zhang1 and Gao Chen1

1Department of Neurosurgery, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310000, China

Correspondence to:

Jian Shi, email: shijian201511@126.com

Gao Chen, email: d-chengao@zju.edu.cn

Keywords: lncHERG; proliferation; migration; miR-940; glioblastoma

Received: September 29, 2017     Accepted: October 27, 2017     Published: November 14, 2017

ABSTRACT

Long noncoding RNAs have recently been proven to regulate tumorgenesis in many cancers. However, their biological functions in glioblastoma remain largely unknown. Here we found an uncharacteristic lncRNA lncHERG that is highly expressed in human glioblastoma (GBM). We found that lncHERG knockdown inhibited cell proliferation, migration and invasion in glioblastoma in vitro and in vivo. Moreover, the higher expression of lncHERG in patients with glioblastoma indicated lower survival rate and poorer prognosis. Mechanistically, we found that lncHERG can serve as a sponge for miR-940 which is a tumor suppressor in cervical cancer and whose function has not been defined in glioblastoma. We showed that miR-940 was down-regulated in glioblastoma tissues compared to peritumor tissues. LncHERG knockdown impaired cell proliferation, migration and invasion while inhibition of miR-940 in the meantime reversed this trend. In conclusion, our study highlights the essential role of lncHERG in glioblastoma by acting as a competing endogenous RNA of miR-940, which may serve as a new prognostic biomarker in glioblastoma.


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PII: 22446