Research Papers:

The association between elevated fasting plasma glucose levels and carotid intima-media thickness in non-diabetic adults: a population-based cross-sectional study

Yalin Guan _, Changshen Yu, Min Shi, Jingxian Ni, Yanan Wu, Hongfei Gu, Lingling Bai, Jie Liu, Jun Tu, Jinghua Wang and Xianjia Ning

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Oncotarget. 2017; 8:111053-111063. https://doi.org/10.18632/oncotarget.22302

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Yalin Guan1,*, Changshen Yu1,*, Min Shi2,3, Jingxian Ni2,3, Yanan Wu2,3, Hongfei Gu4, Lingling Bai2,3, Jie Liu2,3, Jun Tu2,3,5, Jinghua Wang2,3,5,6 and Xianjia Ning2,3,5,6

1Department of Neurology, Tianjin Huanhu Hospital, Tianjin, China

2Department of Neurology, Tianjin Medical University General Hospital, Tianjin, China

3Department of Epidemiology, Tianjin Neurological Institute, Tianjin, China

4Department of Neurology, Tianjin Haibin People’s Hospital, Tianjin, China

5Tianjin Neurological Institute, Key Laboratory of Post-Neuroinjury Neuro-Repair and Regeneration in Central Nervous System, Ministry of Education and Tianjin City, Tianjin, China

6Central of Clinical Epidemiology, Tianjin Medical University General Hospital, Tianjin, China

*These authors have contributed equally to this work

Correspondence to:

Yalin Guan, email: [email protected]

Xianjia Ning, email: [email protected], [email protected]

Keywords: carotid intima media thickness; fasting plasma glucose; risk factors; ultrasonography; epidemiology

Received: March 07, 2017    Accepted: October 12, 2017    Published: November 06, 2017


We assessed the association between the mean carotid intima-media thickness (CIMT) and fasting plasma glucose (FPG) levels in a low-income population in rural China. Adults aged ≥45 years without a history of diabetes, stroke, or cardiovascular disease were recruited. All participants were categorized into four groups according to FPG level. A total of 3509 participants were analyzed in this study. In the univariate analysis, sex, age, education level, hypertension, central obesity, current smoking, alcohol consumption, and higher levels of FPG, total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) were associated with mean CIMT and frequency of increased CIMT. FPG levels were significantly associated with mean CIMT; each 1-mmol/L increase in FPG resulted in a 2.75-μm increase in mean CIMT when adjusted by age, sex, education level, current smoking status, alcohol consumption, hypertension, and the levels of TC, TG, HDL-C, and LDL-C (P = 0.044). However, the association between FPG and the frequency of increased CIMT disappeared after adjusting by covariates. These findings indicate that FPG is an independent determinant of mean CIMT in a non-diabetic population. Management and control of FPG levels is crucial for preventing atherosclerosis in populations with high stroke risks in China.

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