Oncotarget

Research Papers:

A core program of gene expression characterizes cancer metastases

Franz Hartung, Yunguan Wang, Bruce Aronow and Georg F. Weber _

PDF  |  HTML  |  Supplementary Files  |  How to cite  |  Order a Reprint

Oncotarget. 2017; 8:102161-102175. https://doi.org/10.18632/oncotarget.22240

Metrics: PDF 757 views  |   HTML 2463 views  |   ?  


Abstract

Franz Hartung1, Yunguan Wang2, Bruce Aronow2 and Georg F. Weber1

1University of Cincinnati Academic Health Center, Cincinnati, OH, USA

2Computational Medicine Center, Cincinnati Children’s Hospital, Cincinnati, OH, USA

Correspondence to:

Georg F. Weber, email: georg.weber@uc.edu

Keywords: metastasis; metabolism; vascularization; extracellular matrix; ion homeostasis

Received: July 28, 2017    Accepted: August 31, 2017    Published: November 02, 2017

ABSTRACT

While aberrant expression or splicing of metastasis genes conveys to cancers the ability to break through tissue barriers and disseminate, the genetic basis for organ preference in metastasis formation has remained incompletely understood. Utilizing the gene expression profiles from 653 GEO datasets, we investigate whether the signatures by diverse cancers in various metastatic sites display common features. We corroborate the meta-analysis in a murine model. Metastases are generally characterized by a core program of gene expression that induces the oxidative metabolism, activates vascularization/tissue remodeling, silences extracellular matrix interactions, and alters ion homeostasis. This program distinguishes metastases from their originating primary tumors as well as from their target host tissues. Site-selectivity is accomplished through specific components that adjust to the target micro-environment. The same functional groups of gene expression programs are activated in the metastases of B16-F10 cells to various target organs. It remains to be investigated whether these genetic signatures precede implantation and thus determine organ preference or are shaped by the target site and are thus a consequence of implantation. Conceivably, chemotherapy of disseminated cancer might be more efficacious if selected to match the genetic makeup of the metastases rather than the organ of origin by the primary tumor.


Creative Commons License All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 3.0 License.
PII: 22240