Eradicating cancer cells: struggle with a chameleon
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*Department of Tumorimmunology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
Received: February 24, 2011; Accepted: February 28, 2011; Published: February 28, 2011;
Ruurd Torensma, e-mail:
Eradication of cancer stem cells to abrogate tumor growth is a new treatment modality. However, like normal cells cancer cells show plasticity. Differentiated tumor stem cells can acquire stem cell properties when they gain access to the stem cell niche. This indicates that eradicating of stem cells (emptying of the niche) alone will not lead to eradication of the tumor. Treatment should be directed to cancer stem cells ànd more mature cancer cells.
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