Functional polymorphisms in NR3C1 are associated with gastric cancer risk in Chinese population
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Yayun Gu1,2,*, Bin Deng3,*, Jing Kong1,2,*, Caiwang Yan1,2, Tongtong Huang1,2, Jianshui Yang1,2, Yan Wang4, Tianpei Wang1,2, Qi Qi1,2, Guangfu Jin1,2, Jiangbo Du1,2, Yanbing Ding3 and Li Liu2,4
1Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, China
2Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Medicine, Nanjing Medical University, Nanjing, China
3Department of Gastroenterology, Affiliated Hospital of Yangzhou University, Yangzhou, China
4Digestive Endoscopy Center, The First Affiliated Hospital of Nanjing Medical University and Jiangsu Province Hospital, Nanjing, China
*These authors have contributed equally to this work
Jiangbo Du, email: [email protected]
Yanbing Ding, email: [email protected]
Li Liu, email: [email protected]
Keywords: polymorphism; NR3C1; gastric cancer; Chinese population
Received: August 29, 2017 Accepted: September 20, 2017 Published: October 27, 2017
Recently promoter of NR3C1 has been found to be high methylated in gastric cancer tissues which might be involved in the initiation of gastric carcinoma development. To test whether the variants in NR3C1 could modify the risk of gastric cancer, we evaluated the association between four SNPs (rs6194, rs12521436, rs33388 and rs4912913) in NR3C1 and gastric cancer risk in a case-control study with 1,113 gastric cancer cases and 1,848 cancer-free controls in a Chinese population. We found a significant association between rs4912913 and gastric cancer risk (OR=1.18, 95%CI=1.05-1.33, P=5.49×10-3). We also observed that the A-allele of rs12521436 and rs33388 were significantly associated with a decreased risk of gastric cancer (OR=0.84, 95%CI=0.76-0.94, P=2.78×10-3; OR=0.85, 95%CI=0.75-0.97; P=0.018). Finally, we made a joint effect analysis of rs12521436, rs33388 and rs4912913 on risk of gastric cancer (PTrend=2.83×10−5). These findings indicate that the variants rs4912913, rs33388 and rs12521436 of NR3C1 may contribute to gastric cancer susceptibility.
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