Angiotensin II receptor type 1 A1166C modifies the association between angiotensinogen M235T and chronic kidney disease
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Sui-Lung Su1,*, Wei-Teing Chen2,*, Po-Jen Hsiao3, Kuo-Cheng Lu4, Yuh-Feng Lin5, Chin Lin1, Wen Su6, Shih-Jen Yeh7, Hung Chang8 and Fu-Huang Lin1
1School of Public Health, National Defense Medical Center, Taipei, Taiwan
2Division of Thoracic Medicine, Department of Medicine, Cheng Hsin General Hospital, Taipei, Taiwan
3Division of Nephrology, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan
4Division of Nephrology, Department of Medicine, Cardinal Tien Hospital, School of Medicine, Fu Jen Catholic University, New Taipei City, Taiwan
5Division of Nephrology, Department of Medicine, Shuang Ho Hospital, Graduate Institute of Clinical Medicine, Taipei Medical University, Taipei, Taiwan
6Department of Nursing, Tri-Service General Hospital, Taipei, Taiwan
7Office of The President, Da-Yeh University, Changhua, Taiwan
8Department of Physiology and Biophysics, National Defense Medical Center, Taipei, Taiwan
*These authors have contributed equally to this work
Fu-Huang Lin, email: firstname.lastname@example.org
Keywords: chronic kidney disease; renin-angiotensin system; polymorphism
Received: June 05, 2017 Accepted: October 02, 2017 Published: October 26, 2017
Single nucleotide polymorphisms (SNPs) in renin-angiotensin system (RAS) genes are associated with RAS imbalance and chronic kidney disease (CKD). We performed a case-control study and meta-analysis to investigate the association between angiotensinogen (AGT) M235T polymorphism and CKD. A total of 634 patients with end-stage renal disease and 739 healthy controls were studied. We also searched PubMed and the Cochrane Library to identify prospective observational studies published before December 2015. We found that the TT and MT genotypes were associated with a higher risk of CKD than the MM genotype (odds ratio [OR]: 3.56; 95% confidence interval [CI]: 1.14–11.16 and OR: 2.93; 95% CI: 0.91–9.46, respectively). Thirty-eight study populations were included in the meta-analysis. The T allele was associated with a higher risk of CKD than the M allele in all populations (OR: 1.19; 95% CI: 1.08–1.32). The OR was 1.33 in Asians (95% CI: 1.06–1.67) and 1.10 in Caucasians (95% CI: 1.02–1.18). Evaluation of gene-gene and gene-environment interactions using epistasis analysis revealed an interaction between AGT M235T and angiotensin II receptor type 1 A1166C in CKD (OR: 0.767; 95% CI: 0.609–0.965). Genetic testing for CKD in high-risk individuals may be an effective strategy for CKD prevention.
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