Novel characteristics of alpha-fetoprotein (AFP)-producing gastric cancer
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Wenhui Sun1,*, Baoqing Liu2,*, Juntao Chen2,*, Ping Gong3,*, Xiaoying Wu2,4, Chen Liu2, De Zhou5, Bo Hong6 and Weihua Gong2
1Department of Surgery, Fuyang People's Hospital, Hangzhou City, People's Republic of China
2Department of Surgery and Medicine, Second Affiliated Hospital of School of Medicine, Zhejiang University, Hangzhou City, People's Republic of China
3Department of Oncology, The First Affiliated Hospital, Shihezi University School of Medicine, Shihezi City, People's Republic of China
4Tongde Hospital of Zhejiang Province, Hangzhou City, People's Republic of China
5Department of Hematology, First Affiliated Hospital of Medical School of Zhejiang University, Hangzhou City, People's Republic of China
6Department of Pathology, Second Affiliated Hospital of Medical School of Zhejiang University, Hangzhou City, People's Republic of China
*These authors contributed equally to this work
Wenhui Sun, email: firstname.lastname@example.org
Weihua Gong, email: email@example.com
Keywords: novelcharacteristics; AFP; non-AFP-producing; gastric cancer
Received: July 05, 2017 Accepted: October 02, 2017 Published: October 30, 2017
Background: Although serum AFP level is increased in the AFP-producing gastric cancer (GC) patient, AFP-producing GC may become recurrent without re-elevation of serum AFP level. Therefore, novel characteristics of AFP-producing GC such as other biomarkers are to be explored.
Results: 35 AFP-GC and 48 non-AFP-GC patients were included. Our present study revealed that blood type O (15 cases, 42.8%) and A (18 cases, 37.5%) were predominantly observed among AFP-GC and non-AFP-GC patients, respectively. Intriguingly, the least consistently was blood type AB (8.5%, 14.6%). Among AFP-GC patients, pre-operative serum AFP levels were weakly and reversely associated with pre-operative percentage of lymphocytes in the peripheral blood (R2 = 0.1556). The level of alkaline phosphatase (ALP) was highly correlated with the level of lactate dehydrogenase (LDH) (R2 = 0.6682) and CEA (R2 = 0.6813). The level of CEA was moderately correlated with the level of LDH (R2 = 0.3903). By contrast, no any associations between ALP, LDH, CEA, AFP, and peripheral lymphocytes were observed among those 48 non-AFP-GC patients.
Materials and Methods: Retrospective analysis was carried out for 2773 inpatients of gastric cancer from January 2012 to November 2016 in the Second Affiliated Hospital of Zhejiang University School of Medicine.
Conclusions: The aggressive biological features of AFP-producing GC are closely associated with abnormality of other tumor biomarkers and decrease of the proportion of peripheral lymphocytes, implying that post-operative increase of peripheral lymphocytes might benefit GC patients. Combined use of multiple biomarkers is of significance in comprehensive evaluation of AFP-producing GC patients and assessment for those with high risk of cancer recurrence.
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