Relationship of tumor size with pathological and prognostic factors for hilar cholangiocarcinoma
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Hai-Jie Hu1,*, Rong-Xing Zhou1,*, Anuj Shrestha1,2, Yong-Qiong Tan1, Wen-Jie Ma1, Qin Yang1, Jiong Lu1, Jun-Ke Wang1, Yong Zhou1 and Fu-Yu Li1
1Department of Biliary Surgery, West China Hospital of Sichuan University, Chengdu, Sichuan Province, China
2Department of General Surgery, Gandaki Medical College, Pokhara, Nepal
*Co-author and contributed equally to this work
Fu-Yu Li, email: email@example.com
Yong Zhou, email: firstname.lastname@example.org
Keywords: hilar cholangiocarcinoma, prognostic factors, DeOliveira staging system, tumor size, survival outcome
Received: June 08, 2017 Accepted: September 23, 2017 Published: October 23, 2017
Objective: To determine the correlation of different tumor-size cutoffs with prognostic factors and survival outcomes to provide a reference for the modification of the T-stage classification in the DeOliveira staging system for hilar cholangiocarcinoma (HCCA).
Materials and Methods: We retrospectively analyzed 216 patients who underwent curative surgery for HCCA (mean tumor diameter, 2.8 cm) between 2000 and 2013. Univariate and multivariate logistic regression were used to assess the correlation of tumor-size cutoffs with various factors.
Results: Tumor differentiation (odds ratio [OR]: 1.649, 95% confidence interval [CI]: 1.065–2.555, P = 0.025), node status (OR: 1.971, 95% CI: 1.060–3.664, P = 0.032), resection margin (OR: 2.465, 95% CI: 1.024–5.937, P = 0.044), and hepatectomy (OR: 2.373, 95% CI: 1.226–4.593, P = 0.01) were independently correlated with the 2-cm cutoff, while tumor differentiation (OR: 1.755, 95% CI: 1.062–2.091, P = 0.028), node status (OR: 2.166, 95% CI: 1.054–4.452, P = 0.035), and tumor margin (OR: 2.539, 95% CI: 1.089–5.919, P = 0.031) were independently associated with the 3-cm cutoff.
Conclusions: The 2-cm and 3-cm cutoffs were strongly correlated with resection margin, node status, tumor differentiation and survival. The 2-cm cutoff may be added to the DeOliveira staging system.
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