Research Papers:

Relationship of tumor size with pathological and prognostic factors for hilar cholangiocarcinoma

Hai-Jie Hu, Rong-Xing Zhou _, Anuj Shrestha, Yong-Qiong Tan, Wen-Jie Ma, Qin Yang, Jiong Lu, Jun-Ke Wang, Yong Zhou and Fu-Yu Li

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Oncotarget. 2017; 8:105011-105019. https://doi.org/10.18632/oncotarget.22054

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Hai-Jie Hu1,*, Rong-Xing Zhou1,*, Anuj Shrestha1,2, Yong-Qiong Tan1, Wen-Jie Ma1, Qin Yang1, Jiong Lu1, Jun-Ke Wang1, Yong Zhou1 and Fu-Yu Li1

1Department of Biliary Surgery, West China Hospital of Sichuan University, Chengdu, Sichuan Province, China

2Department of General Surgery, Gandaki Medical College, Pokhara, Nepal

*Co-author and contributed equally to this work

Correspondence to:

Fu-Yu Li, email: [email protected]

Yong Zhou, email: [email protected]

Keywords: hilar cholangiocarcinoma, prognostic factors, DeOliveira staging system, tumor size, survival outcome

Received: June 08, 2017     Accepted: September 23, 2017     Published: October 23, 2017


Objective: To determine the correlation of different tumor-size cutoffs with prognostic factors and survival outcomes to provide a reference for the modification of the T-stage classification in the DeOliveira staging system for hilar cholangiocarcinoma (HCCA).

Materials and Methods: We retrospectively analyzed 216 patients who underwent curative surgery for HCCA (mean tumor diameter, 2.8 cm) between 2000 and 2013. Univariate and multivariate logistic regression were used to assess the correlation of tumor-size cutoffs with various factors.

Results: Tumor differentiation (odds ratio [OR]: 1.649, 95% confidence interval [CI]: 1.065–2.555, P = 0.025), node status (OR: 1.971, 95% CI: 1.060–3.664, P = 0.032), resection margin (OR: 2.465, 95% CI: 1.024–5.937, P = 0.044), and hepatectomy (OR: 2.373, 95% CI: 1.226–4.593, P = 0.01) were independently correlated with the 2-cm cutoff, while tumor differentiation (OR: 1.755, 95% CI: 1.062–2.091, P = 0.028), node status (OR: 2.166, 95% CI: 1.054–4.452, P = 0.035), and tumor margin (OR: 2.539, 95% CI: 1.089–5.919, P = 0.031) were independently associated with the 3-cm cutoff.

Conclusions: The 2-cm and 3-cm cutoffs were strongly correlated with resection margin, node status, tumor differentiation and survival. The 2-cm cutoff may be added to the DeOliveira staging system.

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