Single nucleotide polymorphisms rs701848 and rs2735343 in PTEN increases cancer risks in an Asian population
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Dan-Dan Song1,*, Qian Zhang1,*, Jing-Hua Li1,2, Rui-Min Hao1, Ying Ma1, Ping-Yu Wang1,2 and Shu-Yang Xie1
1Key Laboratory of Tumor Molecular Biology in Binzhou Medical University, Department of Biochemistry and Molecular Biology, Binzhou Medical University, Yantai, ShanDong 264003, P.R.China
2Department of Epidemiology, Binzhou Medical University, Yantai, ShanDong 264003, P.R.China
*These authors have contributed equally to this work
Shu-Yang Xie, email: [email protected]
Ping-Yu Wang, email: [email protected]
Keywords: PTEN; SNP; cancer susceptibility; meta-analysis
Received: July 29, 2017 Accepted: September 22, 2017 Published: October 24, 2017
We performed this meta-analysis to analyze the cancer risk to individuals carrying the rs701848 and rs2735343 single nucleotide polymorphisms (SNPs) in the phosphatase and tensin homolog (PTEN) gene. We searched the PubMed, EMBASE, Cochrane library and the national knowledge infrastructure of China (CNKI) databases and identified 18 eligible case-control studies with 5458 cases and 6003 controls for rs701848 as well as 5490 cases and 6209 controls for rs2735343. Our analyses demonstrated that cancer risk was associated with rs701848 in the recessive model (CC vs. CT+TT, OR=1.169, 95% CI: 1.061-1.288) and with rs2735343 in the dominant model (GC+CC vs. GG, OR=0.758, 95% CI: 0.590-0.972). Subgroup analysis showed that in Asian subjects, carrying the C allele of rs701848 or GG genotype of rs2735343 was associated with increased cancer risk. Moreover, Asian subjects carrying the TC/CC genotype or C allele of rs701848 were associated with increased risk of esophageal squamous cell cancer. This meta-analysis indicates that the PTEN rs701848 (CC) and rs2735343 (GG) polymorphisms are associated with increased cancer risk in Asian subjects.
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