Clinical Research Papers:
Use of magnetic resonance imaging for diagnosis and after treatment of patients with myeloid sarcoma of the brain
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Xuewen Hou1, Longting Du1, Haitao Yu2 and Xiaojin Zhang2
1Department of Radiology, Baoan Central Hospital of Shenzhen, Baoan District, Shenzhen 518102, China
2Department of Radiology, Aerospace Center Hospital, Haidian District, Beijing 100049, China
Xuewen Hou, email: email@example.com
Keywords: brain myeloid sarcoma, magnetic resonance imaging, diffusion weighted imaging, arterial spin labeling imaging, susceptibility weighted imaging
Abbreviations: MS: myeloid sarcoma; DWI: diffusion weighted imaging; ASL: arterial spin labeling imaging; SWI: susceptibility weighted imaging
Received: August 01, 2017 Accepted: September 20, 2017 Published: October 13, 2017
The purpose of this retrospective study was to assess the utility of magnetic resonance imaging (MRI) for evaluating post-treatment responses in patients with myeloid sarcoma (MS) of the brain. We evaluated images from both conventional and advanced MR, including diffusion weighted imaging (DWI), arterial spin labeling (ASL) and susceptibility weighted imaging (SWI). Parameters of our qualitative review included lesion location, number, size, morphologic characteristics, surrounding edema, mass effect, pattern and degree of enhancement, ± restricted diffusion, ±susceptibility artifact and ± higher perfusion. Our quantitative assessments were calculated from DW and ASL MR images. The 10 patients had a total of 40 lesions in their brains (mean lesion size of 2.0 ± 0.8 cm). The majority of cases exhibited restricted diffusion (90%) and mild-to-moderate low perfusion (80%). Follow-up MRI after chemotherapy revealed that most lesions (80%) were significantly alleviated after two chemotherapy courses and further improved after four courses. Only a few lesions (5%) were residual after six courses. These findings demonstrate that brain MS can be characterized by changes in various MRI parameters and that MRI can be a useful and predictive assessment tool for brain MS diagnosis and treatment management.
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