Ca2+ signaling in HCO3 secretion and protection of upper GI tract

Jialin He, Xin Yang, Yanjun Guo, Fenglian Zhang, Hanxing Wan, Xuemei Sun, Biguang Tuo and Hui Dong _

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Oncotarget. 2017; 8:102681-102689. https://doi.org/10.18632/oncotarget.21840

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Jialin He1, Xin Yang2, Yanjun Guo2, Fenglian Zhang2, Hanxing Wan2, Xuemei Sun2, Biguang Tuo1 and Hui Dong1,2

1Department of Gastroenterology, Affiliated Hospital, Zunyi Medical College, Zunyi, China

2Department of Gastroenterology, Xinqiao Hospital, Third Military Medical University, Chongqing, China

Correspondence to:

Hui Dong, email: [email protected]

Keywords: calcium signaling, intestinal epithelial, HCO3 secretion, upper gastrointestinal protection

Received: July 23, 2017     Accepted: September 23, 2017     Published: October 12, 2017


The cytosolic calcium ([Ca2+]cyt) is one of the most important cell signaling that can modulate gastrointestinal (GI) epithelial secretion and promote GI mucosal wound repair. The GI mucosal bicarbonate secretion is the main mechanism of mucosal protection. Our research team has been working in this field and provided solid evidence for the important role of Ca2+ signaling in the regulation of GI epithelial secretion and the underlying molecular mechanisms. In this review, we attempt to systemically review the current status of our knowledge on the role of Ca2+ signaling in the regulation of intestinal bicarbonate secretion and in the upper GI epithelial protection. We expect that novel targets could be identified for drug development to better protect GI mucosa and treat mucosal injury with the advance in this filed.

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