Oncotarget

Research Papers:

Genetic polymorphisms in the ALDH2 gene and the risk of ischemic stroke in a Chinese han population

Shuaiqi Sun, Jun He, Yao Zhang, Rongjun Xiao, Mengdan Yan, Yulin Ren, Yuanyuan Zhu, Tianbo Jin _ and Ying Xia

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Oncotarget. 2017; 8:101936-101943. https://doi.org/10.18632/oncotarget.21803

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Abstract

Shuaiqi Sun1, Jun He1, Yao Zhang2, Rongjun Xiao1, Mengdan Yan3, Yulin Ren3, Yuanyuan Zhu3, Tianbo Jin2,3 and Ying Xia1

1Department of Neurosurgery, Haikou People’s Hospital, Xiangya Medical College Affiliated Haikou Hospital, Central South University, Haikou 570311, Hainan, China

2Key Laboratory of High Altitude Environment and Genes Related to Diseases of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang 712082, Shaanxi, China

3School of Life Sciences, Northwest University, Xi’an 710069, Shaanxi, China

Correspondence to:

Tianbo Jin, email: jintianbo@gmail.com

Ying Xia, email: yingxia2017@163.com

Keywords: ischemic stroke; ALDH2; single-nucleotide polymorphism; case-control study

Received: February 28, 2017     Accepted: September 04, 2017     Published: October 10, 2017

ABSTRACT

Background: Previous studies have shown that aldehyde dehydrogenase 2 (ALDH2) plays a role in ischemic stroke progression. In recent years, the activation of the ALDH2 pathway have been reported serving as a useful index in the identification of stroke-prone participants, and the ALDH2 pathway may be a potential target for the therapeutic intervention in ischemic stroke.

Materials and Methods: We evaluated six tagging single-nucleotide polymorphisms (SNPs) of the ALDH2 gene in a case–control study from Hainan of China (488 cases, 503 controls). We used SPSS version 17.0 statistical software, Excel software and other analysis software to explore associations between SNPs and the risk of ischemic stroke various genetic models (additive, dominant, and recessive).

Results: Through statistical analysis, we found that ALDH2 rs886205 [odds ratio (OR) = 6.39; 95% confidence interval (CI) = 1.19-34.38; p = 0.03] and rs7296651 (OR = 9.29; 95% CI = 1.37-63.21; p = 0.02) were associated with increased risk of ischemic stroke in recessive model analysis. In addition, we established that the “AA” genotype (OR = 5.99; 95% CI = 1.11-32.23; p = 0.037) for rs886205 and the “AA” genotype (OR = 8.93; 95% CI = 1.31-60.78; p = 0.025) for rs7296651 were associated with increased ischemic stroke risk.

Conclusions: Our results provide evidence that variants of ALDH2 gene polymorphisms influence the risk of developing ischemic stroke in Han Chinese population.


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