Oncotarget

Research Perspectives:

Targeting Translation Dependence in Cancer

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Oncotarget. 2011; 2:76-88. https://doi.org/10.18632/oncotarget.218

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Abba Malina1, Regina Cencic1, and Jerry Pelletier1,2

1Department of Biochemistry, McIntyre Medical Sciences Building, McGill University, Montreal, Quebec, Canada

2The Rosalind and Morris Goodman Cancer Center, McIntyre Medical Sciences Building, McGill University, Montreal, Quebec, Canada

Keywords: Translation, Translational Control, eIF4F, eIF4E, eIF4A, Translation Inhibitor

Received: February 14, 2011; Accepted: February 14, 2011; Published: February 15, 2011;

Correspondence:

Jerry Pelletier, e-mail:

Abstract

A challenge in cancer therapy is to selectively target activities that are essential for survival of malignant cells while sparing normal cells. Translational control represents a potential anti-neoplastic target because it is exerted by major signaling pathways that are often usurped in cancers. Herein we describe approaches being developed that target eukaryotic initiation factor (eIF) 4F, a heterotrimeric complex that integrates multiple signaling inputs to the translation apparatus.