Targeting Translation Dependence in Cancer
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1Department of Biochemistry, McIntyre Medical Sciences Building, McGill University, Montreal, Quebec, Canada
2The Rosalind and Morris Goodman Cancer Center, McIntyre Medical Sciences Building, McGill University, Montreal, Quebec, Canada
Keywords: Translation, Translational Control, eIF4F, eIF4E, eIF4A, Translation Inhibitor
Received: February 14, 2011; Accepted: February 14, 2011; Published: February 15, 2011;
Jerry Pelletier, e-mail:
A challenge in cancer therapy is to selectively target activities that are essential for survival of malignant cells while sparing normal cells. Translational control represents a potential anti-neoplastic target because it is exerted by major signaling pathways that are often usurped in cancers. Herein we describe approaches being developed that target eukaryotic initiation factor (eIF) 4F, a heterotrimeric complex that integrates multiple signaling inputs to the translation apparatus.
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