Oncotarget

Research Papers:

LDB2 inhibits proliferation and migration in liver cancer cells by abrogating HEY1 expression

Hongyang Yu, Ruichun Jia, Ling Zhao, Shigang Song, Jing Gu and Haogang Zhang _

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Oncotarget. 2017; 8:94440-94449. https://doi.org/10.18632/oncotarget.21772

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Abstract

Hongyang Yu1, Ruichun Jia2, Ling Zhao3, Shigang Song1, Jing Gu4 and Haogang Zhang5

1Department of Radiation Oncology, The Second Affiliated Hospital, Harbin Medical University, Harbin 150086, China

2Department of Blood Transfusion, The Second Affiliated Hospital, Harbin Medical University, Harbin 150086, China

3Oncology Department of Internal Medicine, The Third Affiliated Hospital of Harbin Medical University, Harbin 150040, China

4Department of Anesthesia, The Third Affiliated Hospital of Harbin Medical University, Harbin 150040, China

5Department of General Surgery, The Second Affiliated Hospital, Harbin Medical University, Harbin 150086, China

Correspondence to:

Haogang Zhang, email: wryan2005@163.com

Keywords: HCC, LDB2, BRD7, proliferation, HEY1

Received: July 20, 2017    Accepted: September 20, 2017    Published: October 10, 2017

ABSTRACT

Hepatocellular carcinoma (HCC) was one of the most common cancers around the world, has very low 5-year survival rate. However, the mechanism of HCC occurrence and development is largely unknown. LDB2 belongs to the LIM-domain binding family and functions as an adaptor for transcriptional regulation. Here we found that LDB2 is downregulated in HCC samples. LDB2 has the ability to inhibit proliferation and migration of hepatocarcinoma cells. We found that the proliferation and migration abilities in HCC sample cells were impaired after LDB2 overexpression and vice versa. In mechanism, we found that LDB2 can recruit BRD7 to HEY1 promoter and then block its expression. HEY1 whose expression is upregulated in HCC acts as an oncogene. In brief, our research reveals a new regulatory mechanism for hepatocarcinoma cell proliferation and migration.


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