Research Papers:

The heterogeneous CTV-PTV margins should be given for different parts of tumors during tomotherapy

Ying Tong, Guanzhong Gong, Jinhu Chen, Jie Lu, Tonghai Liu, Pinjing Cheng and Yong Yin _

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Oncotarget. 2017; 8:89086-89094. https://doi.org/10.18632/oncotarget.21631

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Ying Tong2, Guanzhong Gong1, Jinhu Chen1, Jie Lu1, Tonghai Liu1, Pinjing Cheng2 and Yong Yin1

1Radiation Physics Department of Shandong Cancer Hospital Affiliated to Shandong University, Jinan, China

2School of Nuclear Science and Technology, University of South China, Hengyang, China

Correspondence to:

Yong Yin, email: [email protected]

Keywords: tomotherapy, MVCT, setup errors, CTV-PTV margins, heterogeneity

Received: March 29, 2017     Accepted: August 07, 2017     Published: October 06, 2017


Objective: The purpose of this study was to evaluate CTV-PTV margins of tumors for tomotherapy.

Methods: Setup errors were analyzed for 151 patients receiving helical tomotherapy treatment. 53 patients had head and neck tumors, 45 had thoracic tumors, 20 had abdominal tumors, and 33 had pelvic tumors. The setup errors were calculated in six directions, i.e. +X (left), -X (right), +Y (head), -Y (foot), +Z (ventral), and -Z (dorsal), after Megavoltage CT (MVCT) images were registered to simulation CT images. And then the CTV-PTV margins were calculated.

Results: The setup errors along the +Z direction were significantly higher than that along the –Z direction (p<0.05). The CTV-PTV margins on +X, -X, +Y, -Y, +Z, and -Z directions were asymmetric for all tumors, and the heterogeneity were more remarkable on the +Z and –Z directions. The CTV-PTV margins on +Z and –Z were 4.1 mm, 4.6 mm, 5.2 mm, and 8.4 mm; and 3.9 mm, 7.7 mm, 3.3 mm, and 7.7 mm for head and neck tumors, thoracic tumors, abdominal tumors, and pelvic tumors, respectively.

Conclusions: The CTV-PTV margins for patients with different types of tumors were heterogeneous during tomotherapy. The individual margins of six directions should be given for those patients who accept tomotherapy.

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