Aberrant pattern of regional cerebral blood flow in Alzheimer’s disease: a voxel-wise meta-analysis of arterial spin labeling MR imaging studies

Hai Rong Ma, Ping Lei Pan, Li Qin Sheng, Zhen Yu Dai, Gen Di Wang, Rong Luo, Jia Hui Chen, Pei Rong Xiao, Jian Guo Zhong _ and Hai Cun Shi

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Oncotarget. 2017; 8:93196-93208. https://doi.org/10.18632/oncotarget.21475

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Hai Rong Ma1, Ping Lei Pan2, Li Qin Sheng1, Zhen Yu Dai3, Gen Di Wang2, Rong Luo2, Jia Hui Chen2, Pei Rong Xiao2, Jian Guo Zhong2 and Hai Cun Shi2

1Department of Neurology, Traditional Chinese Medicine Hospital of Kunshan, Kunshan, PR China

2Department of Neurology, Affiliated Yancheng Hospital, School of Medicine, Southeast University, Yancheng, PR China

3Department of Radiology, Affiliated Yancheng Hospital, School of Medicine, Southeast University, Yancheng, PR China

Correspondence to:

Jian Guo Zhong, email: [email protected]

Hai Cun Shi, email: [email protected]

Keywords: Alzheimer’s disease, arterial spin labeling, default mode network, meta-analysis, seed-based d mapping

Received: May 18, 2017     Accepted: September 20, 2017     Published: October 04, 2017


Many studies have applied arterial spin labeling (ASL) to characterize cerebral perfusion patterns of Alzheimer’s disease (AD). However, findings across studies are not conclusive. A quantitatively voxel-wise meta-analysis to pool the resting-state ASL studies that measure regional cerebral blood flow (rCBF) alterations in AD was conducted to identify the most consistent and replicable perfusion pattern using seed-based d mapping. The meta-analysis, including 17 ASL studies encompassing 327 AD patients and 357 healthy controls, demonstrated that decreased rCBF in AD patients relative to healthy controls were consistently identified in the bilateral posterior cingulate cortices (PCC)/precuneus, bilateral inferior parietal lobules (IPLs), and left dorsolateral prefrontal cortex. The meta-regression analysis showed that more severe cognitive impairment in the AD samples correlated with greater decreases of rCBF in the bilateral PCC and left IPL. This study characterizes an aberrant ASL-rCBF perfusion pattern of AD involving the posterior default mode network and executive network, which are implicated in its pathophysiology and hold promise for developing imaging biomarkers.

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