miR-1 as a tumor suppressive microRNA targeting TAGLN2 in head and neck squamous cell carcinoma

Nijiro Nohata; Yaeko Sone; Toyoyuki Hanazawa; Miki Fuse; Naoko Kikkawa; Hirofumi Yoshino; Takeshi Chiyomaru; Kazumori Kawakami; Hideki Enokida; Masayuki Nakagawa; Makio Shozu; Yoshitaka Okamoto; Naohiko Seki

doi:10.18632/oncotarget.213

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Research Papers:

miR-1 as a tumor suppressive microRNA targeting TAGLN2 in head and neck squamous cell carcinoma

Nijiro Nohata, Yaeko Sone, Toyoyuki Hanazawa, Miki Fuse, Naoko Kikkawa, Hirofumi Yoshino, Takeshi Chiyomaru, Kazumori Kawakami, Hideki Enokida, Masayuki Nakagawa, Makio Shozu, Yoshitaka Okamoto and Naohiko Seki _

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Oncotarget. 2011; 2:29-42. https://doi.org/10.18632/oncotarget.213

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Abstract

Nijiro Nohata^1,2,*, Yaeko Sone^1,3,*, Toyoyuki Hanazawa², Miki Fuse¹, Naoko Kikkawa^1,2, Hirofumi Yoshino⁴, Takeshi Chiyomaru⁴, Kazumori Kawakami⁴, Hideki Enokida⁴, Masayuki Nakagawa⁴, Makio Shozu³, Yoshitaka Okamoto²,and Naohiko Seki¹

¹Department of Functional Genomics, Chiba University Graduate School of Medicine, Chiba, Japan

²Department of Otorhinolaryngology/Head and Neck Surgery, Chiba University Graduate School of Medicine, Chiba, Japan

³Department of Gynecologic Oncology, Chiba University Graduate School of Medicine, Chiba, Japan

⁴Department of Urology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan

^*These authors contributed equally to this work.

Keywords: microRNA, miR-1, TAGLN2, tumor suppressor, HNSCC, microarray, oncogenes, oncotargets

Received: December 20, 2010; Accepted: January 23, 2011; Published: January 25, 2011;

Correspondence:

Nijiro Nohata, e-mail:

Abstract

Based on the microRNA (miRNA) expression signatures of hypopharyngeal and esophageal squamous cell carcinoma, we found that miR-1 was significantly down-regulated in cancer cells. In this study, we investigated the functional significance of miR-1 in head and neck squamous cell carcinoma (HNSCC) cells and identified miR-1-regulated novel cancer pathways. Gain-of-function studies using miR-1 revealed significant decreases in HNSCC cell proliferation, invasion, and migration. In addition, the promotion of cell apoptosis and cell cycle arrest was demonstrated following miR-1e transfection of cancer cells. A search for the targets of miR-1 revealed that transgelin 2 (TAGLN2) was directly regulated by miR-1. Silencing of TAGLN2 significantly inhibited cell proliferation and invasion in HNSCC cells. Down-regulation of miR-1 and up-regulation of TAGLN2 were confirmed in HNSCC clinical specimens. Our data indicate that TAGLN2 may have an oncogenic function and may be regulated by miR-1, a tumor suppressive miRNA in HNSCC. The identification of novel miR-1-regulated cancer pathways could provide new insights into potential molecular mechanisms of HNSCC carcinogenesis.

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Research Papers:

miR-1 as a tumor suppressive microRNA targeting TAGLN2 in head and neck squamous cell carcinoma

Abstract