HOTAIR regulates HK2 expression by binding endogenous miR-125 and miR-143 in oesophageal squamous cell carcinoma progression
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Jian Ma1,*, Yanxin Fan2,*, Tingting Feng1,3,*, Fangjun Chen4, Zhipeng Xu1, Suqing Li1, Qingfeng Lin1, Xiaoting He1, Weihong Shi1,5, Yang Liu6, Zhihua Liu7, Bin Zhu1 and Xiufeng Cao1
1Department of Surgical Oncology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210008, Jiangsu Province, China
2Jiangsu Cancer Hospital, Medical School of Nanjing University, Nanjing 210008, Jiangsu Province, China
3Institute of Biology and Medical Sciences, Jiangsu Key Laboratory of Infection and Immunity, Soochow University, Suzhou 215123, Jiangsu Province, China
4The Comprehensive Cancer Centre of Drum Tower Hospital, Medical School of Nanjing University, Clinical Cancer Institute of Nanjing University, Nanjing 210008, Jiangsu Province, China
5Yancheng Vocational Institute of Health Sciences, Yancheng 224005, Jiangsu Province, China
6Department of Pharmacy, No.401 Hospital of Chinese People's Liberation Army, Qingdao 266071, Shandong Province, China
7State Key Laboratory of Molecular Oncology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences, Beijing 100021, China
*These authors have contributed equally to this work
Zhihua Liu, email: [email protected]
Xiufeng Cao, email: [email protected]
Bin Zhu, email: [email protected]
Keywords: HOTAIR, miR-125, miR-143, ESCC, HK2
Received: June 15, 2017 Accepted: August 08, 2017 Published: May 04, 2018
Esophageal Squamous Cell Carcinoma (ESCC) is one of the most common malignant cancers worldwide with a high death rate worldwide. Long non-coding RNA (LncRNA) has been recently demonstrated to play a critical role in ESCC. LncRNA HOTAIR played important regulatory roles in ESCC. We highlight the molecular mechanisms by which HOTAIR could influence the expression of Hexokinase 2 (HK2) in ESCC through binding miR-125 and miR-143 directly. Taken together, this study identified a functional lncRNA HOTAIR involved with regulation of glycolysis via miRNA-125/miRNA-143-HK2 in ESCC cells. The “competitive endogenous RNA” (ceRNA) model of HOTAIR/miR-125 and miR143/HK2 interaction might serve as important targets for ESCC diagnosis and therapy.
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