Oncotarget

Reviews:

Molecular hydrogen: a preventive and therapeutic medical gas for various diseases

Li Ge, Ming Yang, Na-Na Yang, Xin-Xin Yin and Wen-Gang Song _

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Oncotarget. 2017; 8:102653-102673. https://doi.org/10.18632/oncotarget.21130

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Abstract

Li Ge1, Ming Yang2, Na-Na Yang3, Xin-Xin Yin2 and Wen-Gang Song4

1Department of Histology and Embryology, School of Basic Medical Sciences, Taishan Medical University, Tai-an City 271000, Shandong Province, PR China

2Department of Clinical Medicine, Taishan Medical University, Tai-an City 271000, Shandong Province, PR China

3Key Laboratory of Atherosclerosis in Universities of Shandong, Taishan Medical University, Institute of Atherosclerosis, Taishan Medical University, Tai-an City 271000, Shandong Province, PR China

4Department of medical immunology, School of Basic Medical Sciences, Taishan Medical University, Tai-an City 271000, Shandong Province, PR China

Correspondence to:

Wen-Gang Song, email: s.com@163.com

Keywords: molecular hydrogen, selective anti-oxidation, gaseous signal modulator, preventive and therapeutic applications

Received: April 27, 2017     Accepted: August 26, 2017     Published: September 21, 2017

ABSTRACT

Since the 2007 discovery that molecular hydrogen (H2) has selective antioxidant properties, multiple studies have shown that H2 has beneficial effects in diverse animal models and human disease. This review discusses H2 biological effects and potential mechanisms of action in various diseases, including metabolic syndrome, organ injury, and cancer; describes effective H2 delivery approaches; and summarizes recent progress toward H2 applications in human medicine. We also discuss remaining questions in H2 therapy, and conclude with an appeal for a greater role for H2 in the prevention and treatment of human ailments that are currently major global health burdens. This review makes a case for supporting hydrogen medicine in human disease prevention and therapy.


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