Oncotarget

Reviews:

MicroRNAs in lung cancer

Diana Castro, Márcia Moreira, Alexandra Monteiro Gouveia, Daniel Humberto Pozza and Ramon Andrade De Mello _

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Oncotarget. 2017; 8:81679-81685. https://doi.org/10.18632/oncotarget.20955

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Abstract

Diana Castro1, Márcia Moreira1, Alexandra Monteiro Gouveia1,2,3, Daniel Humberto Pozza1,3 and Ramon Andrade De Mello4,5,6

1Department of Experimental Biology, Faculty of Medicine, University of Porto, Porto, Portugal

2Institute for Cellular and Molecular Biology (IBMC), Institute for Health Innovation, University of Porto, Porto, Portugal

3Faculty of Nutrition and Food Sciences, University of Porto, Porto, Portugal

4Department of Biomedical Sciences and Medicine, University of Algarve, Faro, Portugal

5Department of Medicine, Faculty of Medicine, University of Porto, Porto, Portugal

6Cearense School of Oncology, Ceará Cancer Institute, Fortaleza, Brazil

Correspondence to:

Ramon Andrade De Mello, email: ramondemello@doctors.org.uk

Keywords: microRNAs, lung cancer, inflammation, epithelial mesenchymal transition, interleukin 1

Received: April 12, 2017     Accepted: August 26, 2017     Published: September 16, 2017

ABSTRACT

Lung cancer (LC) is a serious public health problem responsible for the majority of cancer deaths and comorbidities in developed countries. Tobacco smoking is considered the main risk factor for LC; however, only a few smokers will be affected by this cancer. Current screening methods are focused on identifying the early stages of this malignancy. Thus, new data concerning the roles of microRNA alterations in inflammation, epithelial-mesenchymal transition and lung disease have increased hope about LC pathogenesis, diagnosis, treatment and prognosis. MicroRNA mechanisms include angiogenesis promotion, cell cycle regulation by modulating cellular proliferation and apoptosis, and migration and invasion inhibition. In this context, this manuscript reviews the current information about many important microRNAs as they relate to the initiation and progression of LC.


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