Research Papers:

Association of opioid receptor mu 1 (OPRM1) A118G polymorphism (rs1799971) with nicotine dependence

Xiangyi Kong, Hao Deng, Theodore Alston, Yanguo Kong and Jingping Wang _

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Oncotarget. 2017; 8:84329-84337. https://doi.org/10.18632/oncotarget.20939

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Xiangyi Kong1,2,*, Hao Deng2,*, Theodore Alston2, Yanguo Kong1 and Jingping Wang2

1Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Dongcheng District, Beijing 100730, P. R. China

2Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Harvard University, Boston, Massachusetts 02114-3117, United States of America

*These authors have contributed equally to this work

Correspondence to:

Jingping Wang, email: [email protected]

Yanguo Kong, email: [email protected]

Keywords: OPRM1-A118G, rs1799971, polymorphism, nicotine dependence, meta-analysis

Received: April 12, 2017    Accepted: July 26, 2017    Published: September 15, 2017


Background and Object: Whether opioid-receptor mu 1 (OPRM1) A118G polymorphism (rs1799971) is associated with nicotine dependence is controversial. We analyzed the combined results from published studies of this possibility.

Methods: Literature reviews were performed according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Web of Science, Chinese National Science Infrastructure (CNKI), PubMed, Embase and Google Scholar database searches using MeSH terms were conducted to find all relevant researches up to October 2016. Odds ratios (ORs) and their 95% confidence intervals (95% CIs) were calculated in allele, homozygote, heterozygote, dominant and recessive models. Ethnicity-specific subgroup meta-analysis, heterogeneity, sensitivity analysis and publication bias were considered.

Results: Seven eligible studies with 3313 patients were included. The ORs in the five genetic models mentioned above were 1.000 (95% CI: 0.906, 1.104; p = 0.999), 1.032 (95% CI: 0.771, 1.381; p = 0.834), 0.963 (95% CI: 0.799, 1.162; p = 0.696), 1.006 (95% CI: 0.916, 1.104; p = 0.907), 0.967 (95% CI: 0.715, 1.309; p = 0.830), respectively. Only in dominant model is the association significant. Upon ethnicity-specific subgroup analysis, there is no statistical significance.

Conclusion: OPRM1-A118G polymorphism (A>G) is not associated with nicotine dependence.

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