Research Papers:

Selenium suppresses inflammation by inducing microRNA-146a in Staphylococcus aureus-infected mouse mastitis model

Weijing Sun, Qi Wang, Yingfang Guo, Yifan Zhao, Xinying Wang, Zhenbiao Zhang, Ganzhen Deng and Mengyao Guo _

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Oncotarget. 2017; 8:110949-110964. https://doi.org/10.18632/oncotarget.20740

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Weijing Sun1,*, Qi Wang1,*, Yingfang Guo1,*, Yifan Zhao1, Xinying Wang1, Zhenbiao Zhang1, Ganzhen Deng1 and Mengyao Guo1

1College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, People’s Republic of China

*These authors have contributed equally to this work

Correspondence to:

Mengyao Guo, email: [email protected]

Keywords: selenium, mastitis, S. aureus, miRNA-146, inflammation

Received: June 20, 2017     Accepted: August 04, 2017     Published: September 08, 2017


We studied the effects of selenium (Se) on the inflammatory response in Staphylococcus aureus (S. aureus)-infected mastitis-model mice and mammary epithelial cells. In infected mice, Se elicited a dose-dependent decrease in mammary gland pathology that included inflammatory cell infiltration, disorganized acinar structure and mammary cell necrosis. Se decreased inflammation by increasing miR-146a and decreasing TLR2/6 as well as NF-κB and MAPK signaling pathways in mammary tissue from infected mice and mammary epithelial cells. A miR-146a inhibitor suppressed the anti-inflammatory effects of Se in infected mammary epithelial cells. Se, miR-146a and TLR2 were associated in determining the inflammatory response in mouse with infection-induced mastitis. Thus, Se inhibits pro-inflammatory responses in mammary tissues from S. aureus-infected mice by inducing miR-146a.

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