Genetic polymorphisms in cyclin D1 are associated with risk of renal cell cancer in the Chinese population
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Jianxin Xue1,2,*, Zhiqiang Qin1,*, Xiao Li3,*, Jianzhong Zhang1, Yuxiao Zheng1, Weizhang Xu4, Qiang Cao1 and Zengjun Wang1
1Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China
2Department of Urology, The Second Affiliated Hospital of Southeast University, Nanjing, 210003, China
3Department of Urologic Surgery, The Affiliated Cancer Hospital of Jiangsu Province of Nanjing Medical University, Nanjing, 210009, China
4Department of Thoracic Surgery, Nanjing Medical University Affiliated Cancer Hospital, Jiangsu Key Laboratory of Molecular and Translational Cancer Research, Cancer Institute of Jiangsu Province, Nanjing, 210009, China
*These authors have contributed equally to this work
Zengjun Wang, email: [email protected]
Qiang Cao, email: [email protected]
Keywords: cyclin D1, polymorphism, renal cell cancer, genetic susceptibility
Received: May 16, 2017 Accepted: August 06, 2017 Published: September 08, 2017
Recently, the functional polymorphisms in Cyclin D1 (CCND1) have been shown the potential influence to risk of renal cell cancer (RCC). Therefore, the present study was performed to investigate whether these polymorphisms could influence the susceptibility of RCC. Four potentially functional polymorphisms in CCND1 (rs1944129, rs7177, rs9344 and rs678653) were genotyped in this hospital-based case-control study, comprising of 1,488 RCC patients and 1,677 cancer-free controls in a Chinese population by the TaqMan assay. The logistic regression was used to assess the associations between CCND1 polymorphisms and the risk of RCC. We found the genotype and allele frequency distribution of rs1944129 and rs7177 were significantly associated with risk of RCC (P = 0.015 and P = 0.018, respectively). The analysis of combined risk alleles revealed that patients with 2-4 risk alleles showed an elevated risk of RCC compared to those with 0-1 risk alleles (OR = 1.35, 95% CI = 1.15 - 1.58, P < 0.001). Furthermore, compared with the genotypes containing G allele (AG and GG), the patients carrying the AA genotype in CCND1 rs1944129 polymorphism had a significantly greater prevalence of high clinical stage disease (OR = 0.56, 95% CI = 0.33 - 0.94, P = 0.029). These results suggested that these CCND1 polymorphisms rs1944129 and rs7177 might contribute to the susceptibility of RCC in the Chinese population.
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