Oncotarget

Clinical Research Papers:

Clinicopathologic features and prognostic factors for patients with colorectal cancer who are 75 years and older

Mingfang Zhao, Hans Liu, Yanqing Tang, Xin Meng, Jun Yu, Qi Wang, Qiao Zhou, Sean X. Leng and Haiyan Zhang _

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Oncotarget. 2017; 8:80002-80011. https://doi.org/10.18632/oncotarget.20656

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Abstract

Mingfang Zhao1, Hans Liu2, Yanqing Tang3, Xin Meng4, Jun Yu5, Qi Wang6, Qiao Zhou6, Sean X. Leng2 and Haiyan Zhang6

1Department of Medical Oncology, The First Hospital of China Medical University, Shenyang, P.R. China

2Division of Geriatric Medicine and Gerontology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA

3Department of Psychiatry, The First Affiliated Hospital of China Medical University, Shenyang, P.R. China

4Department of Biochemistry and Molecular Biology, College of Basic Medical Sciences of China Medical University, Shenyang, P.R. China

5Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

6Department of Geriatrics, The First Hospital of China Medical University, Shenyang, P.R. China

Correspondence to:

Haiyan Zhang, email: zhy_doctor@qq.com

Keywords: clinicopathologic features, prognostic factors, colorectal cancer, aged 75 years and over

Received: November 30, 2016     Accepted: July 11, 2017     Published: September 06, 2017

ABSTRACT

Colorectal cancer (CRC) is common and can be considered as a disease of older adults. About one half of the cases were diagnosed in patients over 70 years of age. Decision-making about treatment for these older patients can be complicated by age-related physiological changes, impaired functional status, limited social support, and comorbidities. Many trials excluded patients using an upper limit of 75 years of age. Little is known about prognostic factors in patients who are over this age limit. In this study, we conducted an analysis in the Surveillance, Epidemiology and End Results (SEER) database to identify specific clinicopathologic features and prognostic factors for these vulnerable cancer patients (N= 293,616). They were predominantly female and had more stage I and II diseases in comparison to younger patients. On average, these patients had lower 5-year cause-specific mortality than younger patients (41.98% vs. 63.14%, P<0.001). Gender, marital status, ethnicity, Tumor-Node-Metastasis stage, grade, histologic subtype, tumor size, status of surgery and radiotherapy were all independent prognostic factors for these elderly CRC patients. In particular, surgery could improve prognosis for all CRC patients with the exception of those who are older than 94 years old and with stage III disease. The identified clinicopathologic features and prognostic factor will help guide treatment decision-making for this oldest old subset of patients with CRC.


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