Oncotarget

Research Papers:

Genetic variations in LIGHT are associated with susceptibility to ankylosing spondylitis in a Chinese Han population

Bin Yang, Junlong Zhang, Lixin Li, Xiaojun Lyu, Wei Wei, Zhuochun Huang, Bei Cai and Lanlan Wang _

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Oncotarget. 2017; 8:91415-91424. https://doi.org/10.18632/oncotarget.20644

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Abstract

Bin Yang1,*, Junlong Zhang1,*, Lixin Li1,*, Xiaojun Lyu2,*, Wei Wei2, Zhuochun Huang1, Bei Cai1 and Lanlan Wang1

1Department of Laboratory Medicine, West China Hospital, Sichuan University, Sichuan 610041, China

2West China School of Medicine, Sichuan University, Sichuan 610041, China

*These authors have contributed equally to this work

Correspondence to:

Lanlan Wang, email: wanglanlan_lab@163.com

Keywords: genetic polymorphisms, LIGHT, BTLA, ankylosing spondylitis

Received: February 09, 2017    Accepted: August 04, 2017    Published: September 05, 2017

ABSTRACT

Ankylosing spondylitis (AS) is a common chronic autoimmune disease characterized by inflammation of axial skeleton and has strong genetic susceptibility. Single nucleotide polymorphisms (SNPs) have been found playing an important role in the development of AS. This study intends to explore whether the susceptibility to AS is associated with rs2171513 C>T, rs1077667 G>A in LIGHT (lymphotoxin, expressed on T lymphocytes) and rs12609318 A>G in B and T lymphocyte attenuator (BTLA) in a Chinese Han population. We studied a total of 497 AS patients and 387 healthy controls in the current research. Clinical characteristics were recorded when they were recruited. Single nucleotide polymorphisms (SNPs) were genotyped by polymerase chain reaction (PCR) and high-resolution melting methods (HRM). Statistically significant difference was found in both co-dominant model (GG vs. GA vs. AA) (p = 4.00E-06) and alleles (p = 4.59E-08) of rs1077667 between patients and controls. There was also a significant difference in alleles of rs2171513 (p = 0.037) between patients and controls. We found rs1077667 in LIGHT and rs2171513 in BTLA with susceptibility to AS, while 12609318 in LIGHT associate with susceptibility to AS. Our results showed that LIGHT might be involved in pathogenesis of AS.


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