Oncotarget

Research Papers:

Prognostic significance of total metabolic tumor volume on 18F-fluorodeoxyglucose positron emission tomography/ computed tomography in patients with diffuse large B-cell lymphoma receiving rituximab-containing chemotherapy

Chin-Chuan Chang, Shih-Feng Cho, Ya-Wen Chuang, Chia-Yang Lin, Shu-Min Chang, Wen-Ling Hsu and Ying-Fong Huang _

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Oncotarget. 2017; 8:99587-99600. https://doi.org/10.18632/oncotarget.20447

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Abstract

Chin-Chuan Chang1,2, Shih-Feng Cho3, Ya-Wen Chuang1, Chia-Yang Lin1, Shu-Min Chang1, Wen-Ling Hsu1 and Ying-Fong Huang1,4

1Department of Nuclear Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan

2Institute of Clinical Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan

3Division of Hematology & Oncology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan

4Department of Medical Imaging and Radiological Sciences, Kaohsiung Medical University, Kaohsiung, Taiwan

Correspondence to:

Ying-Fong Huang, email: huangyfnm@gmail.com

Keywords: diffuse large B-cell lymphoma; MTV; TLG; FDG PET/CT; prognosis

Received: May 09, 2017    Accepted: July 25, 2017    Published: August 24, 2017

ABSTRACT

Purpose The purpose of this study was to determine the prognostic significance of metabolic parameters on pre-treatment 18F-fluorodeoxyglucose positron emission tomography/ computed tomography (FDG PET/CT), in patients with diffuse large B-cell lymphoma (DLBCL) receiving rituximab-containing therapy.

Materials and Methods From September 2009 to December 2014, DLBCL patients who had received FDG PET/CT scans for staging were enrolled. The maximal standardized uptake value of tumor (SUVt) was recorded. The metabolic tumor volume (MTV) was the volume of lesion with an elevated SUV greater than 2.5. The total lesion glycolysis (TLG) was the sum of the products of MTV and mean SUV in all measured lesions. Univariate and multivariate analyses were used to assess the prognostic significance of maximal SUVt, total MTV, TLG and other clinical parameters.

Results There were 118 patients enrolled in this study. The median follow-up time was 28.7 months. The 5-year progression-free survival (PFS) for patients with higher and lower total MTV was 32.3% and 66.0% respectively (p = 0.0001). The 5-year overall survival (OS) for patients with higher and lower total MTV was 34.3% and 69.9% respectively (p < 0.0001). Multivariate analysis revealed, besides IPI, that total MTV was independently predictive for PFS (HR: 2.31, 95% CI: 1.16 – 4.60, p = 0.0180) and OS (HR: 2.38, 95% CI: 1.12 – 5.04, p = 0.024). TLG and maximal SUV of tumor were not independent prognostic factors.

Conclusions An elevated total MTV was a predictor for shorter PFS and OS in patients with DLBCL receiving rituximab-containing therapy, independent of IPI.


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