Oncotarget

Research Papers:

Association of PPP1R13L and CD3EAP polymorphisms with risk and survival of non-small cell lung cancer in Chinese non-smoking females

Xu Feng, Xue Fang, Lingzi Xia, Yangwu Ren, Xuelian Li, Xiaowei Quan and Baosen Zhou _

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Oncotarget. 2017; 8:78749-78756. https://doi.org/10.18632/oncotarget.20224

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Abstract

Xu Feng1,2, Xue Fang1,3, Lingzi Xia1,3, Yangwu Ren1,3, Xuelian Li1,3, Xiaowei Quan1,3 and Baosen Zhou1,3

1Department of Epidemiology, School of Public Health, China Medical University, Liaoning, China

2Department of Health Statistics, School of Public Health, Shenyang Medical College, Liaoning, China

3Key Laboratory of Cancer Etiology and Prevention (China Medical University), Liaoning Provincial Department of Education, Liaoning, China

Correspondence to:

Baosen Zhou, email: bszhou@mail.cmu.edu.cn

Keywords: PPP1R13L, CD3EAP, single nucleotide polymorphism, non-small cell lung cancer

Received: April 11, 2017    Accepted: July 19, 2017    Published: August 12, 2017

ABSTRACT

PPP1R13L and CD3EAP were confirmed to play important roles in transcription and apoptosis. SNPs in PPP1R13L and CD3EAP may be associated with lung cancer risk and survival. This study investigated the association of PPP1R13L rs1005165 and CD3EAP rs967591 with non-small cell lung cancer (NSCLC) risk and survival in Chinese non-smoking females. 442 NSCLC cases and 480 cancer-free controls were conducted in the case-control study, and 283 cases were in cohort study. Genotype was determined by Taqman real-time PCR. The statistical analyses were performed by SPSS 22.0 software. We found that rs1005165 and rs967591 were significantly associated with NSCLC risk in Chinese non-smoking females. For rs1005165, compared with homozygous wild CC genotype, carriers of CT or TT genotype had lower risk of NSCLC (adjusted ORs were 0.675 and 0.713, 95% CI were 0.461-0.988 and 0.525-0.968, respectively), adjusted OR for dominant model was 0.702, 95% CI was 0.526-0.937. For rs967591, AA genotype (adjusted OR = 0.721, 95% CI = 0.532-0.978) and at least one A allele (GA+AA) (adjusted OR = 0.716, 95% CI = 0.536-0.956) were significantly correlated with lower risk of NSCLC, compared with GG genotype. But we didn’t find correlation between the two SNPs and survival time in Chinese non-smoking NSCLC females. In general, we found PPP1R13L rs1005165 and CD3EAP rs967591 might be associated with lower NSCLC risk in Chinese non-smoking females, but no significant relationship was found with NSCLC survival.


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