Oncotarget

Research Papers:

Prognostic value of integrin variants and expression in post-operative patients with HBV-related hepatocellular carcinoma

Liming Shang, Xinping Ye, Guangzhi Zhu, Hao Su, Zhixiong Su, Bin Chen, Kaiyin Xiao, Lequn Li, Minhao Peng and Tao Peng _

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Oncotarget. 2017; 8:76816-76831. https://doi.org/10.18632/oncotarget.20161

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Abstract

Liming Shang1,*, Xinping Ye1,*, Guangzhi Zhu1,*, Hao Su1, Zhixiong Su1, Bin Chen1, Kaiyin Xiao1, Lequn Li2, Minhao Peng1 and Tao Peng1

1Department of Hepatobiliary Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, China

2Department of Hepatobiliary Surgery, Affiliated Tumor Hospital of Guangxi Medical University, Nanning, China

*These authors have contributed equally to this work

Correspondence to:

Tao Peng, email: [email protected]

Keywords: integrin, SNPs, ITGA5, ITGB5, hepatocellular carcinoma

Received: January 17, 2017    Accepted: June 20, 2017    Published: August 10, 2017

ABSTRACT

Integrins are a large family of cell surface receptors that bind extracellular matrix proteins and participate in cancer progression. However, the prognostic value of integrin family genes in post-operative patients with HBV-related hepatocellular carcinoma (HCC) remains unknown. In this study, we investigated 18 single nucleotide polymorphisms (SNPs) in integrin family genes and found that the AG/GG genotypes at rs988574 in ITGA1 predicted a better prognosis compared to carriers of the AA genotype (P = 0.025, HR = 0.69, 95%CI = 0.50–0.96). Moreover, rs988574 genotype combined with serum level of AFP had a better prognostic value in HBV-related HCC patients (P = 0.026, HR = 1.75, 95% CI = 1.07–2.85). Furthermore, we compared the expression of 24 integrin family genes in HBV-related HCC tissues and adjacent normal tissues. Survival analysis demonstrated that expression of three of the family members, ITGA5, ITGB5 and ITGA2B, were significantly associated with the overall survival (OS) or relapse-free survival (RFS) of HBV-related HCC patients. Additionally, patients with lower expression of both ITGA5 and ITGB5 had the best OS and RFS (P = 0.017 and P = 0.002, respectively). Our study demonstrated that rs988574 of ITGA1 and the expression of ITGA5, ITGB5 and ITGA2B are potential independent prognostic bio-markers and therapeutic targets for HBV-related HCC patients and may be useful for the diagnosis of HBV-related HCC.


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