The use of neutrophil to lymphocyte ratio as a predictor for clinical outcomes in spontaneous intracerebral hemorrhage

Zengpanpan Ye, Xiaolin Ai, Fang Fang, Xin Hu, Andrew Faramand and Chao You _

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Oncotarget. 2017; 8:90380-90389. https://doi.org/10.18632/oncotarget.20120

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Zengpanpan Ye1,*, Xiaolin Ai1,*, Fang Fang1,*, Xin Hu1, Andrew Faramand2 and Chao You1

1Department of Neurosurgery, West China Hospital of Sichuan University, Chengdu, Sichuan, China

2Department of Neurosurgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States of America

*These authors contributed equally to this work

Correspondence to:

Chao You, email: [email protected]

Keywords: neutrophil to lymphocyte ratio, intracerebral hemorrhage, meta-analysis

Received: May 13, 2017     Accepted: July 29, 2017     Published: August 10, 2017


Objective: Neutrophil to lymphocyte ratio (NLR) is used as an independent predictor for clinical outcomes in cancers, cardiovascular disorders and ischemic stroke. The prognostic role of NLR in spontaneous intracerebral hemorrhage (sICH) is still controversial. The aim of this report is to conduct a meta-analysis to evaluate the prognostic significance NLR in patients with sICH.

Materials and Methods: All related articles were searched on PubMed, EMBASE, Cochrane Central Register of Controlled Trials followed the PRISMA flow diagram. The quality of eligible studies were evaluated and the related data were extracted by two reviewers independently. The end points included the mortality and poor outcomes and subgroup analyses were performed.

Results: Five studies with 1944 subjects were included and had acceptable quality. The high NLR had a higher risk of in-hospital mortality (OR: 0.97; 95% CI: 0.94–0.99, p = 0.02) and 90-day mortality (OR: 2.43; 95% CI: 1.01–5.83, p = 0.047); without association with the poor outcomes (OR: 1.17; 95% CI: 0.93–1.47, p = 0.18). After subgroup analyses, the high NLR correlated with an increased 90-day mortality in the high cut-off group (OR: 1.56; 95% CI: 1.15–2.13, p = 0.005). The high NLR additionally predicts poor outcomes in smaller hematoma group (OR: 1.16; 95% CI: 1.01–1.32, p = 0.04) and the high cut-off group (OR: 2.20; 95% CI: 1.54–3.14, p < 0.001).

Conclusions: The high NLR was significantly associated with in-hospital and 90-day mortality in patients with sICH. The NLR with cut-off of 7.5 had statistically significant potential for predicting mortality and poor outcomes, regardless of country, time of laboratory test and hematoma volumes.

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