Comparison of 18FDG PET/PET-CT and bone scintigraphy for detecting bone metastases in patients with nasopharyngeal cancer: a meta-analysis

Chuanhui Xu, Ruiming Zhang _, Huanlei Zhang and Zhenyan Zhang

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Oncotarget. 2017; 8:59740-59747. https://doi.org/10.18632/oncotarget.20026

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Chuanhui Xu1,*, Ruiming Zhang1,*, Huanlei Zhang1 and Zhenyan Zhang1

1Department of Radiology, Yidu Central Hospital of Weifang, Qingzhou 262500, Shandong, PR China

*These authors contributed equally to this work as first author

Correspondence to:

Ruiming Zhang, email: [email protected]

Keywords: PET, bone scintigraphy, nasopharyngeal cancer, staging, bone metastases

Received: July 04, 2017     Accepted: July 26, 2017     Published: August 07, 2017


Objective: We performed a meta-analysis to compare the diagnostic efficacy of 18FDG PET/PET-CT and bone scintigraphy (BS) for diagnosing bone metastatic cancers in nasopharyngeal cancer patients.

Results: 6 studies (1238 patients) fulfilled the inclusion criteria. The pooled sensitivities for 18FDG PET/PET-CT and BS were 0.81 (95% confidence interval [CI] = 0.70 to 0.98) and 0.39 (95% CI = 0.26 to 0.54), specificities were 0.99 (95% CI = 0.98 to 0.99) and 0.98 (95% CI = 0.96 to 0.99), and the areas under curve were 0.98 (95% CI = 0.97 to 0.99) and 0.84 (95% CI = 0.81 to 0.87).

Materials and Methods: Several databases were searched for all available articles. We calculated the sensitivities, specificities, diagnostic odds ratios, likelihood ratios, and area under summary receiver operating characteristic curves for 18FDG PET/PET-CT and BS, respectively.

Conclusions: 18FDG PET/PET-CT is superior to BS for diagnosing bone metastases in nasopharyngeal cancer patients.18FDG PET/PET-CT may enhance the diagnosis of bone metastases and provide more accurate information for the optimal management of nasopharyngeal cancer.

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