Research Papers:

Systemic immune-inflammation index predicts the clinical outcome in patients with nasopharyngeal carcinoma: a propensity score-matched analysis

Wenjie Jiang, Yuan Chen, Jin Huang, Dan Xi, Jun Chen, Yingjie Shao, Guoping Xu, Wenming Ying, Jun Wei, Junjun Chen, Zhonghua Ning _, Wendong Gu and Honglei Pei

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Oncotarget. 2017; 8:66075-66086. https://doi.org/10.18632/oncotarget.19796

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Wenjie Jiang1,*, Yuan Chen1,*, Jin Huang1, Dan Xi1, Jun Chen2, Yingjie Shao1, Guoping Xu1, Wenming Ying1, Jun Wei1, Junjun Chen1, Zhonghua Ning1, Wendong Gu1 and Honglei Pei1

1Department of Radiation Oncology, The Third Affiliated Hospital of Soochow University, Changzhou 213003, P.R. China

2Department of Respiratory, The Seventh People’s Hospital of Changzhou, Changzhou 213000, P.R. China

*These authors have contributed equally to this work

Correspondence to:

Zhonghua Ning, email: [email protected]

Wendong Gu, email: [email protected]

Honglei Pei, email: [email protected]

Keywords: SII, nasopharyngeal carcinoma, prognosis, PSM

Received: April 12, 2017    Accepted: June 28, 2017    Published: August 02, 2017


Systemic immune-inflammation index (SII), based on peripheral lymphocyte, neutrophil, and platelet counts, was recently investigated as a prognostic marker in several tumors. However, SII has not been reported in nasopharyngeal carcinoma (NPC). We evaluated the prognostic value of the SII in 327 patients with NPC. Univariate and multivariate analyses were calculated by the Cox proportional hazards regression model. The time-dependent receiver operating characteristics (ROC) curve was used to compare the discrimination ability for OS. PSM (propensity score matching) was carried out to imbalance the baseline characteristics. Our results showed that SII, PLR, NLR and MLR were all associated with OS in NPC patients in the Kaplan-Meier survival analysis. SII (HR: 2.26; 95% CI: 1.40-3.66; P=0.001), NLR (HR: 1.66; 95% CI: 1.08-2.53; P=0.020), and MLR (HR: 1.99; 95% CI: 1.17-3.39; P=0.011) were identified to be the independent prognostic factors. The AUC for SII was bigger than NLR, PLR and MLR for predicting survival in patients with NPC in 3 or 5-years. In the PSM analysis, SII remained an independent predictor for OS in NPC patients (HR=2.08, CI 1.22-3.55, P=0.007). SII is a novel, simple and inexpensive prognostic predictor for patients with NPC. The prognostic value of SII is superior to PLR, NLR and MLR.

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