Oncotarget

Reviews:

miR-708-5p: a microRNA with emerging roles in cancer

Nicholas J. Monteleone and Carol S. Lutz _

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Oncotarget. 2017; 8:71292-71316. https://doi.org/10.18632/oncotarget.19772

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Abstract

Nicholas J. Monteleone1 and Carol S. Lutz1

1Department of Microbiology, Biochemistry, and Molecular Genetics, Rutgers Biomedical and Health Sciences, and the School of Graduate Studies, Health Sciences Campus - Newark, Newark, NJ 07103, USA

Correspondence to:

Carol S. Lutz, email: [email protected]

Keywords: miR-708-5p, miR-708, cancer, tumor suppressor, oncomiR

Received: May 24, 2017     Accepted: July 16, 2017     Published: August 01, 2017

ABSTRACT

MicroRNAs (miRNAs) are small non-coding RNAs that negatively regulate gene expression post-transcriptionally. They are crucial for normal development and maintaining homeostasis. Researchers have discovered that dysregulated miRNA expression contributes to many pathological conditions, including cancer. miRNAs can augment or suppress tumorigenesis based on their expression and transcribed targetome in various cell types. In recent years, researchers have begun to identify miRNAs commonly dysregulated in cancer. One recently identified miRNA, miR-708-5p, has been shown to have profound roles in promoting or suppressing oncogenesis in a myriad of solid and hematological tumors. This review highlights the diverse, sometimes controversial findings reported for miR-708-5p in cancer, and the importance of further exploring this exciting miRNA.


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PII: 19772