Single nucleotide polymorphisms in ZNF208 are associated with increased risk for HBV in Chinese people
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Hengxin Li1,*, Jun Chen2,*, RuiZhi Zhang3, Ran Xu4, Zhe Zhang4, Le Ren4, Qi Yang5,6, Yumei Tian7 and Daxu Li3
1Xi’an Center for Disease Control and Prevention, Xi’an, Shaanxi 710054, China
2Department of Pharmacy, The Ankang Central Hospital, Ankang, Shaanxi 725000, China
3Department of Stomatology, The Ankang Central Hospital, Ankang, Shaanxi 725000, China
4Department of Stomatology, The First Affiliated Hospital, Medical School of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China
5Department of Endocrinology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi 710061, China
6Key Laboratory for Tumor Precision Medicine of Shaanxi Province, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi 710061, China
7Xi'an Mental Health Center, Xi’an, Shaanxi 710061, China
*These authors have contributed equally to this work
Yumei Tian, email: firstname.lastname@example.org
Daxu Li, email: email@example.com
Keywords: ZNF208; SNPs; HBV; susceptibility; Chinese Han population
Received: March 04, 2017 Accepted: May 22, 2017 Published: July 28, 2017
Single nucleotide polymorphisms (SNPs) in ZNF208 may be associated with susceptibility to Hepatitis B virus (HBV). In the current study, we analyzed the association between ZNF208 SNPs and risk of HBV in 242 HBV patients and 300 healthy subjects from the Xi’an area of Chinese Han Population. Of the five SNPs examined, rs2188971 (OR: 1.36, 95% CI: 1.04-1.76, P = 0.022), rs8103163 (OR: 1.40, 95% CI: 1.08-1.82, P = 0.010) and rs7248488 (OR: 1.38, 95% CI: 1.07-1.79, P = 0.014) were correlated with HBV susceptibility based on Chi-square tests. After the P-values were adjusted by Bonferroni correction, there only rs8103163 (P = 0.050) was slightly with increased HBV risk. Additionally, haplotype Ars2188972Trs2188971Ars8103163Ars7248488 (OR = 1.42; 95% C I, 1.10-1.85; P = 0.008) was found to increase susceptibility of suffering from HBV. These findings suggest that ZNF208 polymorphisms may contribute to the development of HBV.
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