Meta-analysis of the association of the CYP2J2 G-50T polymorphism with coronary artery disease
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Jian Chen1, Dong-Fei Wang1, Guo-Dong Fu2, Jie Ding1, Lei-Yang Chen2, Jia-Lan Lv1, Juan Fang1, Xiang Yin1 and Xiao-Gang Guo1,2
1Department of Cardiology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China
2Pujiang Branch of the First Affiliated Hospital, School of Medicine, Zhejiang University, Cardiavascular Center of Middle Zhejiang, Jinhua 322200, China
Xiao-Gang Guo , email: firstname.lastname@example.org
Keywords: CYP2J2, G-50T polymorphism, CAD, meta-analysis
Received: May 07, 2017 Accepted: July 12, 2017 Published: July 24, 2017
The association of the CYP2J2 G-50T polymorphism with coronary artery disease has been explored, but the results remain controversial. Thus, a meta-analysis was conducted to provide a comprehensive estimate of this association. We selected ten articles encompassing 12 independent case-control studies with 7063 cases and 10,453 controls for this meta-analysis. Overall, we found significant associations between the CYP2J2 G-50T polymorphism and coronary artery disease risk in three genetic models (allele model: odds ratio (OR) = 1.19, 95% confidence interval (CI) = 1.05–1.34; homozygote model: OR = 2.25, 95% CI = 1.27–4.01; recessive model: OR = 2.17, 95% CI = 1.22–3.86). In these three genetic models, a significant association was observed in Caucasians but not in Asians when the data were stratified by ethnicity. However, no significant associations were found between the CYP2J2 polymorphism G-50T and coronary artery disease risk in heterozygote model and dominant model. In conclusion, our meta-analysis suggested that the CYP2J2 G-50T polymorphism was associated with coronary artery disease risk in the allele, homozygote and recessive models in Caucasians.
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