Predictive value of preoperative retinal nerve fiber layer thickness for postoperative visual recovery in patients with chiasmal compression
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Jing Zhang1,*, Sunfu Zhang1,*, Yanlin Song2,*, Chenjing Zhu2,*, Min He1, Qingqing Ren1, Baoyin Shan1, Ziqiong Wang1, Yunhui Zeng1 and Jianguo Xu1
1Department of Neurosurgery, West China Hospital of Sichuan University, The First People's Hospital of Yibin, Sichuan, PR China
2West China School of Medicine, West China Hospital of Sichuan University, Sichuan, PR China
*These authors have contributed equally to this work
Jianguo Xu, email: firstname.lastname@example.org
Keywords: retinal nerve fiber layer, optical coherence tomography, visual recovery, chiasmal compression, surgery
Received: April 03, 2017 Accepted: June 11, 2017 Published: July 18, 2017
The aim of this study was to evaluate the predictive role of preoperative retinal nerve fiber layer (RNFL) thickness for postoperative visual recovery in patients with chiasmal compression through performing a meta-analysis. PubMed, EMBASE, Cochrane Library and China National Knowledge Infrastructure were searched for relevant studies. The study and patient characteristics were extracted. Pooled odds ratio (OR) with 95% confidence interval (CI) was calculated to estimate the predictive value of RNFL thickness. Subgroup analyses were also performed. Four studies with 202 patients and 395 eyes were included. The pooled results showed that patients with normal RNFL thickness could achieve better visual recovery compared with those with thin RNFL with the OR of 15.61 (95% CI, 4.09-59.61). Significant heterogeneity was observed (I2 = 54.5%, P=0.086). Publication bias was not present. Normal preoperative RNFL thickness could predict better postoperative visual recovery than thin RNFL in patients with chiasmal compression.
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